摘要
目的探讨合并代谢综合征的冠心病患者生活方式改善后其血清游离脂肪酸(FFA)水平的变化,以及治疗性生活方式对冠心病传统危险因素的影响。方法共筛选135例合并代谢综合征的冠心病患者,分为干预组(A组,冠心病常规药物治疗+强化生活方式干预,n=97)和非干预组(B组,冠心病常规药物治疗,n=38)。分别于入选时和随访结束时测定所有入选患者血清FFA水平,同时采集所有患者的体质指标进行比较。结果 (1)合并代谢综合征的冠心病患者FFA水平与腰围和腰高比显著正相关;(2)治疗性生活方式干预后A组患者腰围、BMI和FFA水平显著低于B组(P<0.05);(3)与基线时比较,A组患者经过平均6个月的治疗性生活方式干预后各体质指标和FFA水平均显著降低(P<0.05)。结论在规范的冠心病药物治疗基础上,治疗性生活方式可以降低合并代谢综合征的冠心病患者FFA水平并改善其体质指标。
Objective To investigate the level of serum free fatty acid （ FFA ） after improving the life style in patients with coronary heart disease complicated metabolic syndrome and the effect of therapeutic life style on traditional risk factors of coronary artery disease. Methods A total of 395 patients with coronary heart disease complicated metabolic syndrome were recruited. Pa- tients were divided into intervention group （group A,conventional drug therapyq- intensive life style intervention,n= 97） and non- intervention group （group B,conventional drug therapy,n： 38） according to the scores of life style. Serum free fatty acid （FFA） was determined by ELASA. The scores of life style was obtained by life style questionnaire. Results （1）The serum FFA of patients with coronary heart disease complicated metabolic syndrome were positively related to waist circumference and waist-high-ratio. （2） Waist circumference,BMI and FFA of group A were significantly lower than those in group B after therapeutic life style in- tervention（P〈0.05）. （3） Compared with the baseline,the constitution index and FFA in group A were significantly lower after 6- months therapeutic life style intervention（P〈0.05）. Conclusion Therapeutic life style can reduce the level of FFA and constitution index of the patients with coronary heart disease Complicated metabolic syndrome.
出处
《重庆医学》
CAS
北大核心
2015年第22期3099-3101,3104,共4页
Chongqing medicine
基金
云南省科技厅基金项目资助(2007C0021)
关键词
生活方式
脂肪酸类
非酯化
代谢综合征
冠心病
危险因素
治疗性生活方式
life style
fatty acids, nonesterified
metabolic syndrome
coronary disease
risk factors
therapeutic life style
