摘要
探讨脾γδT淋巴瘤的临床表现、病理学特征和免疫组化特点。方法对5例脾γδT淋巴瘤的临床病理资料进行分析并文献复习。结果 5例患者男性3例,女性2例,中位年龄44岁。5例脾均有不同程度增大伴发热,其中2例出现肝肿大,均未发现淋巴结受累。镜下肿瘤细胞弥漫浸润脾红髓和髓窦,细胞小或中等大小,胞质较丰富、淡染,核仁不明显,核分裂象常见。免疫组化示瘤细胞CD2、CD3、CD43和CD45RO(+),部分CD56(+),CD4、CD8、TIA1、粒酶B、CD57和perforin均(-)。EBER原位杂交均(-)。结论脾γδT淋巴瘤是较为罕见的成熟T细胞性淋巴瘤,以肝脾肿大、发热为主要临床表现,病情发展迅速,预后往往较差。其正确诊断需要结合临床表现及组织学特点,并除外发生于脾的其他良、恶性病变。
Purpose To investigate the clinical presentation,clinicopathogical characteristics and immunophenotypes of hepato splenic Tγδ cell lymphoma. Methods Five cases of patients included 3 males and 2 females,with median age of44 years. 5 patients presented splennomegaly in varying extent and fever without involvement of lymph node,of which two encountered with hepatomegaly. Histologically,the tumor cells diffusely infiltrated the red pulp and medullary sinus,with small to medium size,abundant and pale cytoplasm,unconspicuous nucleolus and frequent mitotic figures. The tumor cells were posivtive for CD2,CD3,CD43,CD45 RO,partly positive for CD56,and negative for CD4,CD8,TIA1,Granzyme B,CD57,and perforin. In-situ hybridization for EBER was negative. Results Hepatosplenic gamma / delta T-cell lymphoma is a rare immature T cell lymphoma,with main presentation of hepatosplenomegaly and fever. The tumors usually progress rapidly,tending to unfavorable prognosis. A correct diagnosis needs the comprehensive evaluation including the clinical representation and histologic features and exclusion of other benign or / and malignant tumors in spleen.
出处
《诊断病理学杂志》
CSCD
2015年第7期399-401,共3页
Chinese Journal of Diagnostic Pathology
关键词
脾
肝
γδT淋巴瘤
病理学
鉴别诊断
Spleen
Liver
Gamma / delta T-cell lymphoma
Pathology
Differential diagnosis
