摘要
研究表明,从基础代谢到细胞生长、分化、增殖等几乎每一细胞事件都与蛋白质酪氨酸磷酸化过程密切相关[1-4]。这一过程分别受蛋白酪氨酸激酶(protein tyrosine kinases,PTKs)和蛋白酪氨酸磷酸酶(protein tyrosine phosphatases,PTPs)共同调控。PTKs能特异地使蛋白质上的酪氨酸残基磷酸化,而PTPs能使磷酸化的酪氨酸残基去磷酸化,两者相互协调,
Receptor type protein tyrosine phosphatase Q( PTPRQ) is an unusual protein tyrosine phosphatase that has intrinsic dephosphorylating activity for various phosphatidylinositiol and phospho-tyrosine substrates,especially the phosphatidylinositol activity. Recent data show that PTPRQ has an important role in various biological processes and is associated with some diseases. In this article,the structure and function of PTPRQ and the relationship between PTPRQ and diseases were briefly summarized.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2015年第7期1340-1344,共5页
Chinese Journal of Pathophysiology
基金
江西省自然科学基金资助项目(No.20151BAB205002)
南昌大学博士后启动基金助项目(No.06301055)
关键词
受体型蛋白酪氨酸磷酸酶Q
失聪
肿瘤
细胞增殖
Protein tyrosine phosphatase
receptor type Q
Hearing loss
Neoplasms
Cell proliferation