摘要
目的 探讨游离氨基酸配方粉在牛奶蛋白过敏性湿疹中的临床干预效果,为牛奶喂养婴儿湿疹的有效饮食干预提供临床依据。方法 选取2013年1月-2014年11月在本院确诊为湿疹的2-6个月月龄的100例牛奶喂养婴儿,将其随机分为观察组和对照组,每组50例。观察组采用游离氨基酸配方粉,脂溢型及渗出型婴儿可采用单纯中药黄连液局部外敷,回避所有奶类、豆类制品,6个月月龄内暂不添加辅食,避免应用皮质激素药膏。对照组采用普通配方奶粉（品牌不指定）,可在皮肤科进行皮肤治疗。对两组婴儿分别于干预后第2、4、12周进行访视,进行体重监测、睡眠时间调查及外周血检测,并对湿疹缓解、消失情况和时间进行记录,比较两组的临床疗效及缓解时间。结果 干预后第2、4、12周,观察组的特应性皮炎评分、嗜酸粒细胞计数、相对增重率等指标显著优于对照组（P〈0.05）,且皮肤破损、暴露部位抓痕累积积分值显著低于对照组（P〈0.05）。观察组在皮肤、呼吸道、消化道以及全身症状等的缓解时间均显著短于对照组（P〈0.05）;观察组的治疗总有效率为94%,明显高于对照组的86%;且复发率为2%,显著低于对照组的12%,差异有统计学意义（P〈0.05）。结论 游离氨基酸配方粉能够缓解婴儿的牛奶蛋白过敏性湿疹,且能快速判断牛奶蛋白过敏。通过饮食干预能够有效改善湿疹婴儿的皮肤、消化道等症状,提高婴幼儿的生活质量。
Objective To study the clinical intervention effect of free amino acids in the formula fedding eczema infants, for milk feeding babies eczema effective dietary intervention to provide clinical basis. Methods 100 cases of milk-fed eczema infants, aged 2-6 months in our hospital from January 2013 to November 2014 were selected,and they were randomly divided into observation group and control group,with 50 cases in each group.Observation group was used the free amino acid formula powder,butter overflow-type and exudative and berberine solution were applied for them, at the same time,avoiding all milk,soy products, upplementary food also was not added for babies,in 6 months of age,avoiding corticosteroid creams.Control group was given formula milk powder （brand do not specify）,skin treatment can be applied in hospitaLAt 2, 4, 12 weeks after intervention,two groups were interviewed and analysised,the checking item included body weight,sleep time,peripheral blood examination and the disappearance time of eczema.The clinical curative effect and reduce time in, two groups was compared. Results At 2,4,12 weeks after intervention,the indicators of SCORingAD scores,eosinophil count,relative weight gain rate in observation group were better than those of control group （P〈0.05）, and the skin damage and exposed parts of the scratch accumulated integral value in observation group was significantly lower than that of control group （P〈0.05）.The skin symptoms,respiratory symptoms,digestive tract symptoms,such as systemic symptom relief time in observation group was significantly shorter than the control group （P〈0.05）.Observation group total effective rate was 94%,which was significantly higher than 86% in the control group.The recurrence rate in observation group was 2%,which was significantly lower than 12% of control group,the difference was statistically significant（P〈0.05）. Conclusion The milk powder can cure eczema baby＇s skin and also release gastrointestinal symptoms, improve the quality of ch
出处
《中国当代医药》
2015年第20期74-77,共4页
China Modern Medicine
基金
广东省东莞市科技局科研课题(2014105101194)
