摘要
目的探讨母亲孕期不同途径苯暴露与儿童急性淋巴细胞白血病（ALL）的关系。方法通过国内外主要数据库检索到符合分析要求的14篇文献,采用Rev Man 5.2软件进行Meta分析。结果母亲孕期有机溶剂、石油制品、居室装修暴露均能显著增加儿童患ALL的风险（OR=1.21,95%CI：1.03~1.42;OR=1.66,95%CI：1.24~2.23;OR=1.16,95%CI：1.01~1.33）;孕期吸烟与儿童ALL的关系尚不明确。结论母亲孕期有机溶剂、石油制品、居室装修接触是儿童ALL的高危因素,吸烟与儿童ALL的关系有待进一步研究。
Objective The aim of this systematic review was to evaluate the controversial association between the benzene exposure during pregnancy and childhood acute lymphoblastic leukemia. Methods Fourteen relevant published articles were searched from domestic and foreign databases and the meta-analysis was performed after extracting data from included literatures. Results Benzene exposure during pregnancy could increase the risk of childhood acute lymphoblastic leukemia（ ALL）; the pooled odds ratio（ OR） with 95% confidence interval（ CI）was 1. 21（ 1. 03,1. 42） for solvent,1. 66（ 1. 24,2. 23） for petroleum,and 1. 16（ 1. 01,1. 33） for house painting. No association was found between childhood ALL and smoking during pregnancy. Conclusions Benzene exposure in pregnancy is a risk factor for childhood leukemia,further research is necessary on the relationship between childhood ALL and smoking during pregnancy.
出处
《环境卫生学杂志》
2015年第3期247-251,共5页
JOURNAL OF ENVIRONMENTAL HYGIENE
