摘要
目的探讨血清α1酸性糖蛋白（AAG）和同型半胱氨酸（Hcy）水平在2型糖尿病肾病不同肾损害期的应用价值。方法收集本院2013年1-12月住院的2型糖尿病患者128例,根据24h尿白蛋白排泄率（UAER）的不同分为单纯2型糖尿病组、早期糖尿病肾病组和临床糖尿病肾病组,并选择同期健康体检者80例作为健康对照组,分别检测血清肌酐（Cr）、尿素氮（BUN）和Hcy水平,并对检测结果进行统计分析。结果单纯2型糖尿病组、早期糖尿病肾病组、临床糖尿病肾病组血清AAG、Hcy水平有明显差异,差异有统计学意义（P〈0.05）,UAER与血清AAG水平呈正相关（r=0.673,P〈0.05）,与Hcy水平呈正相关（r=0.35,P〈0.05）。结论联合检测血清AAG、Hcy对早期糖尿病肾病的诊断、以及评估糖尿病肾损伤程度具有重要意义。
Objective To investigate the value of serumα1acid glycoprotein（AAG）and Homocysteine（Hcy）in different stage of renal damage in type 2diabetes（T2DM）.Methods a total of 128 patients with T2 DM were recruited from January 2013 to October 2013,According to 24 hurinary albumin excretion rate（UAER）were divided into the first group,the second and third groups,and choose 80 healthy cases over the same period as the normal control group.Serum AAG,Hcy,creatinine（Cr）and blood urea nitrogen（BUN）were detected,the test results were analyzed statistically.Results There were significant differences in type 2diabetes mellitus group,early diabetic nephropathy group,clinical diabetic nephropathy group of the serum AAG,Hcy levels（P〈0.05）,there were positively correlated（r=0.673,P〈0.05）between UAER and serum AAG levels,and were positively correlated（r=0.35,P〈0.05）between UAER and Hcy levels.Conclusion Combined detection of serum AAG,Hcy have a significant for early diagnosis of diabetic nephropathy and assessing the degree of renal injury in diabetes.
出处
《国际检验医学杂志》
CAS
2015年第14期2043-2044,共2页
International Journal of Laboratory Medicine
