摘要
目的探讨尿苷二磷酸葡萄糖醛酸转移酶（UDP-glucuronosyltransferase,UGT）1A7基因多态性与结直肠癌（colorectal cancer,CRC）易感性的关系。方法计算机检索Cochrane图书馆、Pub Med、EMBASE、中国生物医学文献数据库（CBM）、万方数据库（Wanfang Data）中有关CRC易感性与UGT1A7基因多态性易感性病例-对照研究,采用Rev Man 5.1和Stata 12.0软件对纳入研究进行Meta分析。结果共纳入6个研究共1 320例CRC患者和1 860名健康对照人群。Meta分析结果显示,UGT1A7基因多态性与CRC风险具有相关性。UGT1A7＊1：OR=0.62,95%CI：0.35～1.10;UGT1A7＊2：OR=1.02,95%CI：0.90～1.14;UGT1A7＊3：OR=1.41,95%CI：1.26～1.57。基于人种的亚组分析显示,UGT1A7＊1能降低亚洲人群的CRC患病风险率,UGT1A7＊2相关性不大,UGT1A7＊3则能增加CRC患病率。UGT1A7＊1：OR=0.50,95%CI：0.38～0.65;UGT1A7＊2：OR=1.10,95%CI：0.90～1.35;UGT1A7＊3：OR=2.24,95%CI：1.86～2.68;对于欧美人群UGT1A7基因多态与CRC相关性不明显。结论基于目前研究结果显示,野生型UGT1A7＊1与CRC易感性呈负相关,UGT1A7＊3可能与肿瘤易感性升高有关,而UGT1A7＊2与CRC相关性不大。
Objective To systematically explore the correlation between polymorphism of UDP-glucuronosyltransferase 1A7（ UGT1A7） and susceptibility of colorectal cancer（ CRC）. Methods The databases were searched such as Cochrane,Pub Med,EMBASE,CJFD,CBM,Wanfang Data to collect the case-control studies on the correlation between polymorphism of UGT1A7 and susceptibility of CRC,and the Rev Man 5. 1 and Stata 12. 0 were used to perform the Meta-analysis with the included researches. Results A total of 6 studies involving 1 320 CRC patients and 1 860 healthy controls were identified. The results of Meta-analysis showed that there was significant association between polymorphism of UGT1A7 and susceptibility of CRC. UGT1A7 ＊ 1： OR = 0. 62,95% CI： 0. 35 ～ 1. 10; UGT1A7＊ 2： OR =1. 02,95% CI： 0. 90 ～ 1. 14; UGT1A7 ＊ 3： OR = 1. 41,95% CI： 1. 26 ～ 1. 57. The results of subgroup analysis grouped by ethnicity showed that UGT1A7＊ 1 could decrease the rate of Asia＇s population risk of CRC,UGT1A7 ＊ 2had little correlation,and UGT1A7＊ 3 could increase the incidence of CRC. UGT1A7＊ 1： OR = 0. 50,95% CI： 0. 38 ～0. 65; UGT1A7＊ 2： OR = 1. 10,95% CI： 0. 90 ～ 1. 35; UGT1A7 ＊ 3： OR = 2. 24,95% CI： 1. 86 ～ 2. 68. For the European and American,there was no obvious correlation between polymorphism of UGT1A7 and CRC. Conclusion Current evidences suggest that the Wild type UGT1A7 ＊ 1 has negative correlation with susceptibility of CRC,the UGT1A7＊ 3 may be associated with increased susceptibility of cancer,and the UGT1A7＊ 2 has little correlation with it.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第7期781-785,共5页
Chinese Journal of Gastroenterology and Hepatology
