摘要
目的:比较喹硫平联用碳酸锂与阿立哌唑联用碳酸锂在治疗双相障碍抑郁中的疗效及安全性差异。方法:采用随机区组法,将我院94例双相障碍抑郁患者分为喹硫平组及阿立哌唑组,各47例,并给予相应药物治疗8周,比较两组患者在治疗期间汉密顿抑郁量表(HAMD-17)和杨氏躁狂量表(YMRS)得分变化以及不良反应情况、TESS、治疗总有效率间差异。结果:94例病例中,脱落8例,实际参与研究86例。由HAMD-17结果可知,基线期两组差异无统计学意义(P>0.05),随着治疗的进行,其在治疗1、2、4周末差异均有统计学意义(t1周末=5.321,P<0.01;t2周末=4.215,P<0.01;t4周末=2.438,P<0.05),但在第8周末,两组间差异无统计学意义(P>0.05);YMRS结果显示,两组在治疗期间评分均<7;两组治疗有效率差异无统计学意义(χ2=0.199,P>0.05);在不良反应发生情况上两组无明显差异;由TESS结果可知,两组在治疗后第2周末差异有统计学意义(t=2.531,P<0.05),而在随后治疗时间中,差异无统计学意义(P>0.05)。结论:与喹硫平比较,阿立哌唑与碳酸锂联用起效更快,但是两者最终疗效相似,不良反应情况相当。
Objective： Comparison of quetiapine combined with lithium carbonate and aripiprazole combined with lithium carbonate in the treatment of the efficacy and safety of different bipolar depression. Methods： After the randomized block method, the hospitalized 94 patients with bipolar depression into quetiapine group and aripiprazole groups,47 cases in each,who received medication for eight weeks. HAMD-17 and YMRS change and the adverse circumstances,TESS,treatment efficiency difference were compared between the two groups. Results：Among 94 cases,8 cases were lost follow up,thus 86 cases actually participated in the study; the baseline results of HAMD-17 showed no significant differences in the two groups（ P〉0. 05）,whereas those of a 2,4 weekend had some significant differences（ t1 weekend= 5. 321,P〈0. 01; t2 weekend= 4. 215,P〈0. 01; t4 weekend= 2. 438,P〈0. 05）,still in the first 8 weeks,the two groups had no difference（ P〈0. 05）; YMRS showed that scores of both groups during treatment were 〈7; and efficiency in the treatment of the two groups had no significant difference（ χ2= 0. 199,P〉0. 05）; in the case of adverse reactions there was no significant difference of TESS results between the two groups（ t = 2. 531,P〈0. 05）,however in the subsequent treatment time,the difference was not statistically significant（ P〉0. 05）. Conclusion： Combined with lithium carbonate,aripiprazole compared with quetiapine shows faster effects,however the final effect and adverse reactions are similar in the treatment of bipolar disorder.
出处
《现代医学》
2015年第6期748-751,共4页
Modern Medical Journal
