摘要
目的观察多烯磷脂酰胆碱在预防乳腺癌术后辅助化疗致肝损害的临床疗效。方法乳腺癌术后首次辅助化疗患者62例随机分为治疗组32例和对照组30例。2组除常规化疗药物外，治疗组在化疗首日开始每日给予多烯磷脂酰胆碱。观察2组化疗前后丙氨酸氨基转移酶（ALT）和总胆红素（TBIL）变化情况。结果治疗前2组ALT、TBIL指标比较差异无统计学意义（P〉0．05），化疗后治疗组ALT、TBIL水平均低于对照组（P〈0．05或P〈0．01）。结论多烯磷脂酰胆碱能有效减轻乳腺癌术后化疗引起的药物性肝损害。
Objective To observe the liver protecting effect of polyene phosphatidylcholine adjuvant chemotherapy in postoperative breast cancer patients with adjuvant chemotherapy. Methods A total of 62 postoperative breast cancer patients with adjuvant chemotherapy were randomly divided into treatment group （n = 32） and control group （n = 30）. Treatment group were given polyene phos- phatidyl choline since the first day of chemotherapy. The levels of alanine aminotransferase （ALT） and total bilirubin （TBIL） were observed before and after treatment in both groups. Results Before treat- ment, there was no significant difference in ALT and TBIL between two groups（P 〉0.05）, ALT and TBIL were lower in treatment group than those in the control group after treatment （ P 〈 0.01, P 〈 0. 05）. Conclusion Polyene phosphatidyl choline can reduce chemotherapy induced liver damage in postoperative breast cancer patients.
出处
《实用临床医药杂志》
CAS
2015年第E01期37-38,共2页
Journal of Clinical Medicine in Practice
关键词
多烯磷脂酰胆碱
化疗
药物性肝损害
polyene phosphatidyl choline
chemotherapy
drag induced liver injury
