摘要
目的:检测IGF1R、IGFBP3在肺鳞癌组织中的表达,并探讨其在肺鳞癌发生发展中的作用及其临床意义。方法:用免疫组化二步法检测246例肺鳞癌术后组织与40例癌旁正常组织中IGF1R、IGFBP3的表达情况,并分析二者的相关性及与临床病理特征和预后的关系。结果:IGF1R在肺鳞癌组织中的阳性表达明显高于癌旁正常组织,其表达率分别为54.07%、32.5%,IGFBP3在肺鳞癌组织中的阳性表达明显低于癌旁正常组织,其表达率分别为61.79%、87.5%,差异具有统计学意义(P<0.05)。IGF1R的表达与淋巴结转移正相关(P<0.05),IGFBP3的表达与肺癌的TNM分期、淋巴结转移负相关(P<0.01),而与其他临床病理参数无关(P>0.05)。IGF1R阳性表达组患者生存期明显短于IGF1R阴性表达组患者,IGFBP3阳性表达组患者生存期明显长于IGFBP3阴性表达组患者,差异有统计学意义(P分别为<0.001和=0.001)。Cox单因素分析显示TNM分期、淋巴结转移、IGF1R及IGFBP3的表达均与预后相关,将TNM分期、淋巴结转移、IGF1R及IGFBP3的表达进行Cox回归多因素分析,结果显示TNM分期、IGF1R及IGFBP3的表达均为肺鳞癌患者的独立预后因子。IGF1R、IGFBP3在肺鳞癌组织中表达呈负相关(r=-0.204,P<0.001)。结论:IGF1R、IGFBP3参与了肺鳞癌的发生、发展,并且二者均为肺鳞癌的独立预后因子。有望成为分子靶向治疗的新靶点。
Objective： To detect the expression of IGF1 R,IGFBP3 in resected squamous cell lung cancer（ SQCLC） tissue and to explore the correlation of IGF1 R,IGFBP3 with SQCLC occurrence,development. Methods： All246 cases of resected squamous cell lung cancer and 40 cases of adjacent cancer normal tissue were detected for IGF1 R,IGFBP3 protein expression using immunohistochemical methods. Results： Squamous cell lung cancer of IGF1 R positive expression rate was 54. 07%,higher than in adjacent normal tissue 32. 5%,squamous cell lung cancer of IGFBP3 positive expression rate was 61. 79%,lower than in adjacent normal tissue 87. 5%（ P〈0. 05）. IGF1 R expression was related with lymph node metastasis（ P〈0. 05）,IGFBP3 expression was related with the TNM stage,lymph node metastasis（ P〈0. 01）,and had relation to smoking,gender,age. IGF1 R expression-positive patient overrall survival ratio was shorter than the expression-negative of IGF1 R,IGFBP3 expression-positive patient overrall survival ratio was longer than the expression-negative of IGFBP3. Cox regression univariate analysis showed that the squamous cell lung cancer prognosis was related with the TNM stage,lymph node metastasis,the expression of IGF1 R and IGFBP3. Cox regression analysis of multi factors showed that the squamous cell lung cancer prognosis was related with the TNM stage,lymph node metastasis. The expression of IGF1 R and IGFBP3 was negatively correlated（ r =-0. 204,P〈0. 001）. Conclusion： IGF1 R,IGFBP3 are involved in lung squamous cell carcinoma occurrence,development,and the two are the independent prognostic factors in squamous cell carcinoma of lung. And is expected to become a new target for molecular therapy.
出处
《现代肿瘤医学》
CAS
2015年第16期2313-2318,共6页
Journal of Modern Oncology
