摘要
目的探讨卵巢储备功能正常的因输卵管因素接受长方案降调节体外受精-胚胎移植(IVF-ET)成功患者的相关因素,为不孕患者制订个性化助孕方案以提高妊娠率提供依据。方法 Logistic回归分析临床和实验室各参数,寻找各协变量对妊娠结局的影响大小及影响方向(正或负)。结果所有因素中,Gn天数、内膜厚度、Gn总量对妊娠结局影响显著。其中,Gn天数、内膜厚度和优胚数的回归系数B为正,与妊娠呈正相关;而Gn总量系数为负(β=-0.000 34),与妊娠呈负相关。结论子宫内膜越厚,Gn天数适当延长,优胚率增加,适当减少Gn总量,提高IVF妊娠率,其他因素在IVF-ET治疗结局中可能不起作用。
Objective To explore the related factors in the patients with normal ovarian function receiving the successful long down regulation protocol controlled ovarian stimulation（COH）in vitro fertilization and embryo transfer（IVF-ET）to provide the basis for formulating the personalized assisted reproduction scheme to improve the pregnancy rate.Methods The Logistic regression analysis was adopted to analyze the clinical and laboratory parameters for searching the influence extent and direction（positive or negative）of the various concomitant variables on the pregnancy outcome.Results Among all the factors,pregnancy（Gn）duration,endometrial thickness and total Gn amount had significant effects on the pregnancy outcome.The regression coefficient B of Gn duration,endometrial thickness and number of good-quality embryos was positive,showing the positive correlation with the pregnancy,but which of total Gn amount was negative（β=-0.000 34）,showing negative correlation with pregnancy.Conclusion The endometrium thickness is thicker and the Gn duration is extended appropriately,the good-quality embryos rate is increased,and the total Gn amount is appropriately decreased,the IVF-ET pregnant rate is increased.Other factors may not work in the pregnant outcome of IVF-ET.
出处
《检验医学与临床》
CAS
2015年第14期1994-1996,共3页
Laboratory Medicine and Clinic
基金
南京军区医学科技面上项目(2013-MS125)
南京军区福州总医院院内课题(201212)
关键词
体外受精-胚胎移植结局
子宫内膜厚度
Gn天数
优胚数
Gn总量
outcome of in vitro fertilization-embryo transfer
endometrial thickness
Gn duration
number of good-quality embryos
total Gn amount
