摘要
白细胞介素10(IL-10)是由多种细胞分泌的且参与多种细胞生物调节功能的细胞因子,在儿童哮喘、结核病、肺炎支原体肺炎、呼吸系统病毒和细菌感染中,通过调节其他细胞因子的作用而发挥抗炎和免疫调节的作用,从而影响着疾病的转归和预后。目前已成功研制了重组IL-10肽病毒样颗粒疫苗,通过提高体内外IL-10的生物活性来治疗IL-10不足的相关疾病。
Interleukin （ IL）-10 is a kind of cytokine secreted by a variety of cells and participates in a variety of cell biology regulating function .It exerts anti-inflammatory and immunomodulatory effects by modu-lating the action of other cytokines in children with asthma,tuberculosis,pneumonia,mycoplasma pneumonia, respiratory viral and bacterial infections,thereby affecting the prognosis.At present,the restructured IL-10 peptide vaccine virus-like particles have been successfully developed,which treat some diseases due to lack of IL-10 by improving the activity IL-10 in vitro and in vivo.
出处
《医学综述》
2015年第13期2338-2340,共3页
Medical Recapitulate
基金
大连市医学卫生科学研究计划项目(2012-51)
关键词
哮喘
儿童
病毒感染
白细胞介素10
细菌感染
： Asthma
Children
Virus infection
Interleukin-10
Bacterial infection
