摘要
目的探讨异甘草酸镁对重症急性胰腺炎患者炎症反应和脏器功能的影响。方法将92例重症急性胰腺炎患者随机分为试验组46例和对照组46例。对照组给予禁食、胃肠减压、H2受体阻滞剂和生长抑素抑制胰酶分泌、预防性应用抗生素、解痉镇痛、营养支持、补液等基础治疗;试验组在对照组的基础上,给予静脉滴注异甘草酸镁注射液150 mg·d-1,2组疗程均为2周。比较2组的C反应蛋白、肿瘤坏死因子-α、白细胞介素-6和细胞黏附分子-1等炎症指标和氧合指数、谷丙转氨酶、谷草转氨酶、血清肌酸酐、尿素氮等脏器功能指标的差异,以及不良反应发生率。结果试验组总有效率89.13%显著高于对照组69.57%,(P<0.05)。治疗7,14 d后,试验组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6和细胞黏附分子-1均显著低于相同时点的对照组(P<0.05)。治疗7,14 d后,试验组氧合指数显著高于相同时点的对照组,谷丙转氨酶、谷草转氨酶、血清肌酸酐、尿素氮均显著低于相同时点的对照组(P<0.05)。2组患者治疗期间均未发生不良反应(P>0.05)。结论异甘草酸镁可通过改善炎症反应和保护脏器功能而提高治疗重症急性胰腺炎的临床疗效。
Objective To explore the effect of magnesium isoglycyrrhizinate on clinical curative effect in patients with severe acute pancreatitis（ SAP）. Methods Ninety-two SAP patients were randomly divided into the treatment group（ n = 46） and the control group（ n = 46）. They all accepted the conventional treatment,but the patients in the treatment group were given the treatment of magnesium isoglycyrrhizinate150 mg·d-1for 2 weeks. The difference of C reactive protein（ CRP）,tumor necrosis factor alpha（ TNF-α）,interleukin-6（ IL-6）,intercellular adhesion molecule-1（ ICAM-1）,oxygenation index,alanine aminotransferase,aspartate aminotransferase,blood creatinine,urea nitrogen and the incidence rate of adverse drug reactions were compared between the two groups. Results The total effective rate in the treatment group（ 89. 13%） was significantly higher than that in control group（ 69. 57%）. After 7 d and 14 d of treatment,the CRP,TNF-α,IL-6,ICAM-1 in the treatment group were significantly lower than that in the control group（ P〈0. 05）. After 7 d and 14 d of treatment,oxygenation index in the treatment group was significantly higher than that in the control group（ P〈0. 05）, and alanineaminotransferase,aspartate aminotransferase,blood creatinine,urea nitrogen in the treatment group were significantly lower than that in the control group（ P〈0. 05）. Conclusions Magnesium isoglycyrrhizinate could improve the clinical efficacy by improving inflammation and protecting organ function in SAP patients.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第14期1387-1389,共3页
The Chinese Journal of Clinical Pharmacology
关键词
异甘草酸镁
重症急性胰腺炎
炎症反应
脏器功能
magnesium isoglycyrrhizinate
severe acute pancreatitis
inflammation
organ function
