摘要
选择165例2型糖尿病患者，其中合并胫前色素沉着斑（PPP）者80例（PPP组），无PPP者85例（NPPP组），以及50名糖调节正常者为对照组（NGR组）。记录并比较各组患者的性别、年龄、糖尿病病程、体重指数（BMI）、收缩压、舒张压、空腹血糖（FBG）、餐后2h血糖（2hPG）、甘油三酯（TG）、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、HbA1C、视黄醇结合蛋白4（RBP4）、胱抑素C等。结果显示，NPPP组BMI、FBG、2hPG、TG、胱抑素C高于NGR组（P〈0．01）。PPP组患者BMI、收缩压、FBG、2hPG、TG、胱抑素C、RBP4高于NGR组（P〈0．05或P〈0．01）。PPP组患者糖尿病病程、FBG、2hPG、HbAm胱抑素C、RBP4明显高于NPPP组（P〈0．01）。Pearson相关分析显示血清RBP4与胱抑素C呈线性正相关（r=0．77，P〈0．01）。受试者工作特征曲线显示RBP4及胱抑素C曲线下面积分别为0．81、0．78（P〈0．01）。二元logistic回归分析结果显示，糖尿病病程、HbA1C、RBP4与PPP的发生呈正相关（r=0．37、0．26、0．22，P〈0．05或P〈0．01）。
A total of 165 type 2 diabetic patients were divided into two groups with pigmented pretibial pathes（ PPP group）and no PPP（ NPPP group）. 50 subjects with normal glucose regulation were used as a control group（ NGR group）. The records of sex, age, diabetes duration, body mass index （ BMI）, systolic blood pressure （SBP）, diastolic blood pressure, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, fasting blood glucose （FBG） , 2 h postpradial plasma glucose （ 2hPG ）, triglyceride （ TG ） , total cholesterol, HbAlc, retinol binding protein 4 （ RBP4 ）, cystatin C （ Cys C ） were analyzed. The results showed that BMI, FBG, 2hPG, TG, and Cys C levels in NPPP group were higher than those in NGR group（ all P〈0.01 ）. The levels of BMI, SBP, FBG, 2hPG, TG, Cys C, and RBP4 in PPP group were higher than those in NGR group （P〈0.01 or P〈0.05 ）, while diabetes duration, FBG, 2hPG, HbA1c, Cys C, and RBP4 in PPP group were higher than those in NPPP group （P 〈 0. O1 ）. Pearson correlation analysis revealed that serum RBP4 and Cys C were in linear positive correlation（ r=0.77, P〈 0. 01 ）. The areas under receiver operating characteristic curve of RBP4 and Cys C were 0. 81 and 0. 78, respectively （ P〈0.01 ）. The results of binary logistic regression analysis showed that diabetes duration, HbA1c, RBP4 were related to PPP（ r=0.37,0.26, 0.22, P〈0.05 or P〈0.01 ）.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2015年第7期601-603,共3页
Chinese Journal of Endocrinology and Metabolism
