摘要
目的探讨血清超敏c反应蛋白(hs-CRP)在慢性乙型肝炎(CHB)进展中的意义。方法总共182例未经治疗的CHB患者和50名健康对照被纳入研究。对所有患者的血清hs-CRP水平与患者的年龄、性别、病史、血清HBVDNA水平、肝功能、肝脏硬度检测值(LsM)和肝组织纤维化分期进行了相关性分析。计量资料以均数±标准差G士s)表示,正态分布的均数比较用t检验,非正态分布的均数比较用秩和检验;相关性检验采用Pearson相关分析,等级相关性采用Spearman分析。结果CHB患者血清hs-CRP水平[(2.38±2.79)mg/L]显著高于健康对照[(0.78±1.07)mg/hl,t=2.495,P〈0.05。血清hs-CRP水平与患者年龄、性别和病程无明显相关眭泸〉0.05),与HBVDNA水平、总胆红素、ALT、AST和LSM呈正相关(r值分别为0.159,0.271,0.298,0.389,0.562,P值均〈0.05);血清CRP水平与肝功能损害程度、LSM和肝组织纤维化分期呈正相关(r值分别为0.340,0.292,0.434,P值均〈0.01)。结论血清hs-CRP与CHB病毒的复制、肝功能损害程度及肝纤维化进展密切相关,但受肝功能损害程度的影响较大,其能否作为肝纤维化分期的指标尚需深入研究。
Objective To explore the clinical significance of high-sensitivity C-reactive protein (hs- CRP) in the development of chronic hepatitis B (CI-IB). Methods A total of 182 patients with untreated CHB and 50 healthy individuals (controls) participated in the study. Correlation analysis was performed to determine the association of serum hs-CRP with the age, sex, medical history, serum hepatitis B virus (HBV) DNA, liver function parameters, liver stiffness measure (LSM) and hepatic fibrosis; in addition, correlation analysis was carried out for the associations of degree of liver damage with grade of hepatic fibrosis, LSM and the serum levels ofhs-CRP. Results CHB patients showed significantly higher serum hs-CRP levels than healthy controls (2.38±2.79 vs. 0.78±1.07; t = 2.495, P 〈 0.05). Serum hs-CRP levels were significantly correlated with HBV DNA (r = 0.159), liver function parameters (total bilirubin, r = 0.271; alanine aminotransferase, r = 0.298; aspartate aminotransferase, r = 0.389), and LSM, r = 0.562) (all P 〈 0.05). The correlations with liver function (r = 0.340), LSM (r = 0.292) and hepatic fibrosis grade were positive (r = 0.434) (allP 〈 0.01). Conclusion Serum hs-CRP levels in CHB patients can reflect degree of liver damage and of liver fibrosis.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2015年第7期498-501,共4页
Chinese Journal of Hepatology
基金
宁夏科技攻关项目,中国肝炎防治基金会王宝恩肝纤维化研究基金(xjs)