摘要
目的了解重症监护室（ICU）环境中多重耐药鲍曼不动杆菌（MDRAB）的分布及其耐药性,分析MDRAB的流行情况,为ICU耐药菌的预防和控制提供参考。方法于2013年从广州市12间三甲医院ICU中采集184份环境样本、57份医务人员手样本,运用梅里埃VITEK2 Compact进行细菌鉴定及抗菌药物敏感试验（MIC）,药敏结果按CLSI标准判定,数据统计应用WHONET5.6软件处理。结果总共分离到46株MDRAB,其中手样本中分离到1株,床栏、气管插管、记录台、仪器按钮等为主要分布区;46株MDRAB对左氟沙星的耐药率最低（47.6%）,其次为哌拉西林/他唑巴坦（85.7%）,对其他17种抗菌药物的耐药率均很高（90.5%-100%）。结论 ICU环境中MDRAB分布广泛,耐药性非常严重,应加强ICU环境的清洁和消毒,强化医务人员的手卫生操作,以减少耐药菌感染事件的发生。
Objective To investigate the distribution and the antimicrobial resistance among Acinetobacter baumannii isolated from 12 hospitals in Guangzhou during 2013. Methods A total of 241 samples were collected from ICU（Intensive care unit） wards, 184 from environment samples, 57 from the hand of medical staffs. Identification of the isolates was confirmed with the VITEK-2 Compact System. The antimicrobial susceptibility were determined by using the VITEK-2 Compact System and interpreted according to the Clinical and Laboratory Standards Institute guidelines（CLSI）.The data were analyzed by WHONET5.6 software. Results A total of 46 multi-drug resistant A. baumannii（MDRAB）isolates were determined. The MDRAB isolates were predominately isolated from bedside rail, trachea cannula, tabletop,and push-button,one MDRAB was isolted from the hand of medical staff. All the MDRAB isolates were showed high resistant to seventeen antimicrobial compounds（90.5% to 100%）. Fewer than 50% of the MDRAB isolates were resistant to ciprofloxacin,and 85.7% of the MDRAB isolates were resistant to piperacillin / tazobactam. Conclusions The study show a high prevalence of MDRAB isolates in ICU wards. Several methods can be performed to enhance the containment of multidrug-resistant organisms ： environmental disinfection, contact precautions, and hand hygiene.
出处
《热带医学杂志》
CAS
2015年第6期741-743,共3页
Journal of Tropical Medicine
基金
广州市卫生局医药卫生科技项目(20141A010051)
关键词
鲍曼不动杆菌
重症监护室
耐药性
Acinetobacter baumannii
intensive care unit
drug resistance
