摘要
磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/m TOR)信号通路参与调节细胞代谢、生长、增殖、血管生成等多种重要生物过程,其高度激活的状态与多种恶性肿瘤的发生、发展相关。对PI3K/Akt/m TOR信号通路及m TOR蛋白进行了简单的介绍,并阐述了其在肝细胞癌、胆管细胞癌、胆管癌及胆囊癌发生发展中的作用机制,进一步简述了m TOR抑制剂在肝胆恶性肿瘤治疗中的作用。认为PI3K/Akt/m TOR信号通路为晚期肝胆恶性肿瘤提供了新的治疗靶点,新型m TOR抑制剂的不断研发将为晚期肝胆恶性肿瘤患者带来新的希望。
Phosphoinositide- 3 kinase / protein kinase- B / mammalian target of rapamycin（ PI3 K / Akt / m TOR） signaling pathway is involved in many important biological processes such as cell metabolism,growth,proliferation,and angiogenesis. And its high- level activation is closely related to the development and progression of many malignant tumors. In this paper,m TOR and PI3 K / Akt / m TOR signaling pathway are introduced,and their action mechanisms in the development and progression of hepatocellular carcinoma,cholangiocellular carcinoma,cholangiocarcinoma,and gallbladder carcinoma are expounded,and then the role of m TOR inhibitors in the treatment of malignant hepatobiliary tumors is briefly described. It is thought that the PI3 K / Akt / m TOR signaling pathway provides new therapeutic targets for malignant hepatobiliary tumors in advanced stage and the constant development of new m TOR inhibitors provides some new hope for the patients with malignant hepatobiliary tumors in advanced stage.
出处
《临床肝胆病杂志》
CAS
2015年第6期989-991,共3页
Journal of Clinical Hepatology
关键词
肝肿瘤
胆道肿瘤
衔接蛋白质类
信号转导
综述
liver neoplasms
biliary tract neoplasms
adaptor proteins
signal transducing
review
