摘要
长期以来羊水胎粪污染（MSAF）被认为是胎儿宫内缺氧导致胎粪排出所致，曾被认为是胎儿宫内缺氧的同义词，但 MSAF 也可能是胎儿宫内成熟时胎粪排出的自然现象。胎儿宫内缺氧时胎粪排出增加和清除胎粪能力降低是胎儿宫内窘迫 MSAF 的重要机制。MSAF 对机体的损伤与胎粪的浓度、MSAF 持续的时间及引起胎粪排出的原因有关。胎粪通过直接引起胎儿-胎盘循环的血管损伤及通过激活炎性因子释放可能参与胎儿脑损伤的发生，但 MSAF 的意义及与脑损伤之间的关系仍有待进一步深入研究。
For a long time,it was believed that meconium - stained amniotic fluid（MSAF）was caused by fe-tal intrauterine hypoxia induced fetal defecation,once considered synonymous with fetal intrauterine hypoxia. But,MSAF may be a natural phenomenon that mature fetal defecated in intrauterine. Meconium discharge increased and the ability to remove meconium reduced were the important mechanism of the fetal intrauterine distress induced MSAF,when suf-fered from the fetal intrauterine anoxia. MSAF induced damage in the body was associated with the concentration of me-conium,the exposure duration to the meconium amniotic fluid and the causes of meconium discharge. Meconium can di-rectly damage fetal - placental vasculature and promote the release of inflammatory factor,both of them may be involved in the brain injury. The significance of the MSAF and its relationship to brain injury remains for further study.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2015年第14期1046-1050,共5页
Chinese Journal of Applied Clinical Pediatrics
关键词
胎粪
羊水胎粪污染
脑损伤
胎儿
Meconium
Meconium - stained amniotic fluid
Brain damage
Fetal
