摘要
缺血性中风是当今危害人们健康的重要疾病之一。促进中枢神经系统内源性神经干细胞(NSCs)的增殖、分化,从而修复受损的神经元是提高缺血性中风临床疗效的关键点。NSCs的增殖、分化可受多种因素影响,其中Notch信号通路在机体发生缺血性中风时激发内源性NSCs的增殖、分化是必不可少的。从中医学角度看,醒神开窍针刺法可使缺血性中风患者髓海充而复神明,改善中风后"形神失调"的症状,认为其机制与调节Notch信号通路,促进内源性NSCs的增殖、分化有关。
Ischemic stroke is one of the critical diseases endangering people＇s health. Promoting proliferation and differentiation of central nervous system endogenous neural stem cells（ NSCs） to repair damaged neurons was a key point to improve clinical effects on ischemic stroke. Proliferation and differentiation of NSCs can be influenced by many factors,of which Notch signaling pathways stimulates proliferation and differentiation of endogenous NSCs in the body when ischemic stroke happens is essential. From the Chinese medical point of view,acupuncture method of inducing resuscitation may make brain full and recover spirit in patients with ischemic stroke and improve symptoms due to ＂disorder between body and spirit＂after stroke. It is believed that its mechanism is related to adjusting Notch signal pathway and promoting proliferation and differentiation of endogenous NSCs.
出处
《中医杂志》
CSCD
北大核心
2015年第14期1193-1197,共5页
Journal of Traditional Chinese Medicine
基金
中国博士后科学基金(2013M530858
2014T70203)
关键词
缺血性中风
醒神开窍
NOTCH信号通路
神经干细胞
针刺
ischemic stroke
inducing resuscitation
Notch signaling pathway
neural stem cells
acupuncture
