摘要
目的：评价瑞替普酶（rPA）给药方法在治疗急性下肢深静脉血栓中的临床有效性及安全性。方法将187例急性下肢深静脉血栓形成（ADVT）患者随机分为2组，其中静脉快速滴注 rPA 溶栓组85例，24 h 静脉泵入维持 rPA 溶栓组102例。通过对其治疗效果进行分析，比较两组患者治疗前后健患肢大、小腿消肿效果，溶栓效果，溶栓效率及溶栓期间并发症。结果两组患者治疗前后健患肢大、小腿消肿及溶栓效果比较差异均无统计学意义（P 均＞0．05）；24 h 静脉泵入组患者溶栓时间[（4．76±1．56）d]少于静脉快速滴注组溶栓时间[（6．56±0．83）d]，即24 h静脉泵入组溶栓效率高于静脉快速滴注组患者（P ＜0．05）；24 h 静脉泵入组患者溶栓期间并发症发生率（3．9％）明显少于静脉快速滴注组（17．6％）（P ＜0．05）。结论rPA 为治疗 ADVT 疗效好、起效迅速的溶栓药物，经静脉溶栓效果好，但24 h 静脉泵入较静脉快速滴注起效更为迅速，且更为安全。
Objective To investigate the clinical efficacy and safety of reteplase（rPA）adminis-tration in treating acute deep venous thrombosis（ADVT）of lower extremity.Methods A total of 1 87 pa-tients with ADVT were randomly divided into two groups,with 85 patients in rapid intravenous dripping group and 1 02 patients in 24-hour venouspumping group.Their effects on limb swelling,thrombolysis,and complicationswere compared for analysis.Results The differences in the curative effectsof reducingswell-ingand thrombolysis effect between the two groups werenot significant（P 〉0.05）.Thethrombolysis time in the 24-hour venouspumping group was shorter than that of the rapid intravenous dripping group [（4.76 ± 1 .56）days vs（6.56 ±0.83）days,P 〈0.05],indicating 24-hour venouspumping was more effective than rapid intravenous dripping.Complication incidence in the 24-hour venouspumping group was less than that of the rapid intravenous dripping group（3.90% vs 1 7.6%,P 〈0.05）.Conclusion rPA is a goodvenous thrombolytic agentwith rapid effect in treating ADVT.The 24-hour venouspumping was more effective and safe than the rapid intravenous dripping.
出处
《临床外科杂志》
2015年第6期472-474,共3页
Journal of Clinical Surgery
关键词
瑞替普酶
静脉快速滴注
静脉泵入
急性下肢深静脉血栓
reteplase
rapid intravenous dripping
continuously venous-pump
acutedeep venous thrombosis of lower extremity
