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孤独症谱系障碍儿童杏仁核体积研究 被引量:5

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摘要 目的比较孤独症谱系障碍男童和正常发育男童的杏仁核体积,探讨杏仁核体积与孤独症谱系障碍儿童临床表现的相关性。方法采用磁共振成像测量37例孤独症谱系障碍男童和14例正常发育男童的杏仁核体积;采用《0-4岁婴幼儿神经心理发育诊断量表》、《扩大的0-4岁婴幼儿神经心理发育诊断量表》、儿童期孤独症评定量表(CARS)、孤独症行为量表(ABC)对孤独症儿童进行心理评估,分析杏仁核体积与孤独症谱系障碍儿童临床相关指标的关系。结果孤独症谱系障碍组左、右两侧杏仁核体积分别为(1.01±0.39)cm3和(1.06±0.38)cm3,均明显大于对照组〔(0.68±0.37)cm3和(0.73±0.26)cm3〕(P<0.05)。杏仁核体积与孤独症谱系障碍儿童DQ得分、CARS得分、行为量表及相关因子得分无明显相关性(P>0.05)。结论孤独症谱系障碍儿童杏仁核体积大于健康儿童,未发现杏仁核体积与儿童认知水平、疾病程度之间存在相关性。提示杏仁核是孤独症谱系障碍的神经基础之一。
出处 《中国妇幼保健》 CAS 2015年第21期3620-3622,共3页 Maternal and Child Health Care of China
基金 江苏省无锡市科技局社会发展项目〔SCZ00N110〕
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参考文献14

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