摘要
目的对MSCs衰老的特征及发生机制的研究进展进行综述。方法广泛查阅近年来国内外研究MSCs衰老的相关文献,并进行分析总结。结果 MSCs在实验培养传代过程中存在着衰老迹象,表现为形态的衰老变化,增殖、分化能力逐渐减低及免疫调节功能的改变等,影响了其在临床的应用前景。目前关于MSCs衰老机制的研究主要集中在端粒与端粒酶调控、应激损伤等,涉及到端粒酶活性调控机制、p53/p21、P13K/Akt及Wnt/β-连环蛋白等信号通路的调节。结论对MSCs衰老机制的研究有助于加速MSCs向临床应用的转化。
Objective To summarize the research situation of mesenchymal stem cells（MSCs） senescence,including the characteristics and mechanisms of senescence. Methods The original articles in recent years about MSCs senescence were extensively reviewed, and comprehensively analyzed. Results The senescence of MSCs which manifests as morphological senescence, reduced proliferation and differentiation potential, altered immunoregulation are found during the cultivation in experiment, which profoundly affects clinical application of MSCs. The research about the mechanisms of MSCs senescence includes telomere and telomerase, and stress-mediated injury etc, involving regulation of telomerase, and regulation of signal pathways of p53/p21, P13K/Akt, and Wnt/β-catenin etc. Conclusion The further study of senescence mechanisms will help to accelerate the clinical application of MSCs in the future.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2015年第7期899-904,共6页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(31070876
81272035
81201423)~~
关键词
MSCS
衰老
机制
端粒酶
Mesenchymal stem cells
Senescence
Mechanism
Telomerase
