摘要
目的观察不同时间窗超选择眼动脉溶栓治疗视网膜中央动脉阻塞的疗效。方法选取单侧视网膜中央动脉阻塞患者26例。按发病到开始动脉溶栓时间分为A、B两组,其中A组(3 h^72 h)16例,B组(72 h^5 d)10例。均采用Seldinger技术,微导管超选择性眼动脉插管,局部灌注尿激酶250 000~500 000U(10 000 U/min)进行溶栓治疗;比较两组疗效。结果溶栓后A组的视力改善率明显优与B组(87.50%VS 70.00%),并且A组显效率高于B组(37.50%VS 20.00%);对比视力改善率和视网膜动脉灌注改善率,各组视力改善率高于视网膜动脉灌注改善率(A组:87.50%VS 81.25%;B组:70.00%VS 50.00%)。结论超选择眼动脉溶栓是视网膜中央动脉阻塞的安全、有效治疗措施。5 d内进行干预均有效,早期干预组效果好于延迟干预组,但针对具体患者必须遵循个体化治疗原则。
Objective To observe the effect of different time windows super-selective transcatheter thrombolysis for treatment of central retinal artery occlusion .Methods Twenty-six patients with unilateral central retinal artery occlusion were selected .According to the time from onset to arterial thrombolysis , patients were divided into A group （3 h-72 h,n=16） and B group（72 h-5 d,n=10）.Adopting Seldinger technology , microcatheter superselective ophthalmic artery, intravenous infusion of urokinase 250 000-500 000 U（10 000 U/min） for thrombolytic therapy;the curative effects of two groups were compared .Results After thrombolysis the visual improvement rate of A group was significantly better than B group （87.50% VS 70.00%）, and the significant efficiency of A group was higher than that of B group （37.50%VS 20.00%）;contrast visual acuity improvement rate and improvement rate of retinal artery perfusion, visible each vision improvement rate was higher than the retinal arterial perfusion improvement rate （A group： 87.50% VS 81.25%; B group： 70% VS 50%）.Conclusions Superselective ophthalmic artery thrombolysis is a safe , effective treatment of central retinal artery embolism measures .5 d intervention is effective intervention , the effect of early intervention group is better than delayed intervention group , but for the specific patient must follow the principle of individualized treatment .
出处
《临床神经病学杂志》
CAS
北大核心
2015年第3期221-223,共3页
Journal of Clinical Neurology
关键词
视网膜中央动脉阻塞
眼动脉溶栓
时间窗
尿激酶
central retinal artery occlusion
ophthalmic artery thrombolysis
time windows
urokinase
