摘要
目的：探讨氢吗啡酮复合左布比卡因在小儿骶管麻醉中的应用效果。方法选取拟于本院择期行腹股沟斜疝或鞘膜积液手术的患儿50例为研究对象。随机分成 C 组（应用0．20％左布比卡因）和 H 组（应用0．20％左布比卡因复合10 mcg／kg 氢吗啡酮混合液），每组各25例。比较两组苏醒时间，镇痛时间，运动阻滞、瘙痒、躁动发生情况以及苏醒期恶心呕吐、呼吸抑制等并发症的发生情况。结果两组患儿运动阻滞、躁动、恶心呕吐、呼吸抑制等的发生率差异无统计学意义（P ＞0．05），术后2 h、4 h、24 h 东安大略儿童医院疼痛评估评分（CHEOPS 疼痛评分）比较，差异无统计学意义（P ＞0．05）；术后6 h、8 h、10 h，H 组 CHEOPS 疼痛评分显著低于 C 组（P ＜0．01）。相比 C 组，H 组镇痛时间显著延长（P ＜0．05），术后瘙痒的发生率明显增高（P ＜0．05）。结论骶管氢吗啡酮能够安全应用于小儿骶管麻醉及术后镇痛，延长左布比卡因镇痛持续时间，且不影响术后运动阻滞功能，无明显不良反应。
Objetive To evaluate the efficacy of caudal hydromorphone added to levobupivacaine in pe-diatric patients. Methods 50 pediatric patients who were diagnosized as inguinal hernia or hydrocele were enrolled into the study.They were randomly allocated using a computer-generated sequence of numbers to one of the two groups：Group C（caudal 0.2% levobupivacaine,n =25）,Group H（caudal 0.2% levobupivacaine combined with 10mcg/kg hydromorphone,n =25）.Recovery time,the duration of analgesia,residual motor block,pruritus,emergence agitation,postoperative nausea and vomiting,respiratory depression,sides effect were recorded and compared.Results There were no significant difference found in the incidences of residual motor block,residual motor block,emergence agitation,postoperative nausea and vomiting,respiratory depres-sion.The incidences of pruritus in Group H was significantly higer than in Group C.The CHOEPS pain scores at 6h,8h,10h postoperation in group H were significantly lower than those in Group C,However,no signifi-cant difference in postoperative 2 h,4 h,24 h between Group H and Group C.The duration of postoperative analgesia in Group H was significantly longer than it in Group C. Conclusions Caudal hydromorphone im-proves postoperative analgesia and prolongs the duration of analgesia in children without any neurological side effects.
出处
《临床小儿外科杂志》
CAS
2015年第3期234-236,246,共4页
Journal of Clinical Pediatric Surgery
