摘要
目的观察益气化痰颗粒联合羧甲司坦减少慢性阻塞性肺疾病(COPD)稳定期患者急性加重的疗效及安全性。方法纳入COPD稳定期气虚或兼痰阻/血瘀证患者108例,采用区组随机法分为观察组和对照组各54例。对照组口服羧甲司坦并按需吸入支气管舒张剂,观察组在此基础上联合益气化痰颗粒冲服,疗程24周。观察2组治疗期间COPD急性加重次数与程度及治疗前后中医证候评分、肺功能、6 min步行距离变化。结果观察组平均急性加重总次数(0.33±0.55)低于对照组(0.62±0.71),平均重度急性加重次数(0.12±0.33)低于对照组(0.28±0.45),差异均有统计学意义(P<0.05);治疗前后症状评分比较,观察组中医证候总分、喘息/呼吸困难评分、气短乏力评分及6 min步行距离的改善均优于对照组(P<0.05);治疗安全性好。结论益气化痰颗粒联合羧甲司坦治疗COPD稳定期患者,可有效减少COPD急性加重的次数及程度,改善患者中医证候评分及6 min步行距离。
Objective To observe the efficacy and safety of Yiqi Huatan Granules combined withcarbocisteine to reduce the acute exacerbation of chronic obstructive pulmonary disease （COPD）.Methods Totally 108 patients in the stationary phase of COPD with qi deficiency or merging phlegmblockage/blood stasis syndrome were randomly divided into two groups. Patients in the controlgroup were treated with carbocisteine and inhaled bronchodilators on-demand, while patients inthe treatment group were treated with Yiqi Huatan Granules combined with carbocisteine andbronchodilators for 24 weeks. Times and severity of acute exacerbations of COPD, TCM syndromescores, lung function, and 6-minute walking distances of the two groups during the treatmentperiod were observed. Results The average times of acute exacerbations of COPD in the treatmentgroup （0.33 ± 0.55） were fewer than the control group （0.62 ± 0.71）;the average times of severeacute exacerbations of COPD in the treatment group （0.12 ± 0.33） were fewer than the controlgroup （0.28 ± 0.45）, with statistical significance （P 〈 0.05）. Comparison between the TCMsyndrome scores before and after treatment, TCM total syndrome scores, breathless/dyspneascore, breath shortness and fatigue score, and 6-minute walking distance in the treatment groupwere better than the control group （P 〈0.05）, with better safety. Conclusion The treatment of YiqiHuatan Granules combined with carbocisteine for COPD patients can effectively decrease timesand severity of acute exacerbations of COPD, and improve TCM syndrome scores and 6-minutewalking distance.
出处
《中国中医药信息杂志》
CAS
CSCD
2015年第8期43-46,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
北京市中医药科技发展基金项目(JJ2011-74)
关键词
益气化痰颗粒
慢性阻塞性肺疾病
急性加重
中西医结合疗法
Yiqi Huatan Granules
chronic obstructive pulmonary disease
acute exacerbation
integration of traditional Chinese medicine and Western medicine
