摘要
目的探讨血浆同型半胱氨酸水平与2型糖尿病患者颈动脉斑块稳定性的关系。方法选取2型糖尿病患者182例,根据颈动脉超声结果分为无斑块组、稳定斑块组、不稳定斑块组及血管狭窄组。观察4组患者的同型半胱氨酸、血糖、血脂、糖化血红蛋白及CRP等指标。结果动脉狭窄组同型半胱氨酸水平明显高于另外3组(P<0.01),无斑块组同型半胱氨酸水平与不稳定斑块组及动脉狭窄组比较明显降低(P<0.01)。高同型半胱氨酸组脑卒中发生率明显高于低同型半胱氨酸组(P<0.05)。相关分析显示,糖尿病患者的血浆同型半胱氨酸水平与年龄呈正相关(r=0.15,P=0.040),与叶酸呈负相关(r=-0.32,P=0.001)。结论 2型糖尿病患者血同型半胱氨酸水平与颈动脉斑块稳定性及脑卒中发生密切相关。
Objective To investigate the relationship between plasma homocysteine level and the stability of carotid atherosclerotic plaque in patients with type 2 diabetes. Methods A total of 182 patients with type 2 diabetes were assigned to four groups according to the results of the ultrasonography of carotid artery, that was non - plaque group, stable plaque group, instable plaque group and carotid ar- tery stenosis group. The levels of plasma homocysteine, blood glucose, blood lipid, glycosylated hemoglobin and C - reactive protein of the patients were observed. Results The plasma homocysteine levels of patients in the carotid artery stenosis group were significantly higher than patients in the other 3 groups（P 〈 0.01 ）. Compared to the patients in the instable plaque group and carotid artery stenosis group, the plasma homocysteine levels of patients in the non - plaque group were significantly lower（ P 〈 0.01 ）. The levels of homocys- teine in type 2 diabetes were positively correlated with age （ r = 0.15 ,P = 0. 040） and negatively correlated with the levels of serum folic acid （ r = - 0.32, P = 0. 001 ）. Conclusion The plasma homocysteine levels of type 2 diabetes were closely related with the the stability of carotid atherosclerotic plaque and the incidence of stroke.
出处
《医学研究杂志》
2015年第6期107-109,共3页
Journal of Medical Research
