摘要
目的探讨高压氧与尼莫地平联合治疗颅脑损伤所致脑功能障碍的临床疗效。方法选取神经外科2011年2月-2014年2月期间收治的因颅脑损伤所致的脑功能障碍患者124例,根据治疗方法不同将其分为常规治疗组45例、高压氧疗组40例和高压氧联合尼莫地平组(联合治疗组)39例。比较各组患者在治疗前、治疗后2周、治疗后4周的神经功能缺损评分以及脑血流量情况。结果治疗前3组神经功能缺损评分以及脑血流量无统计学差异(P>0.05)。治疗2周和4周后,高压氧疗组、联合治疗组患者的神经功能缺损评分低于常规治疗组,差异有统计学意义(P<0.05),而且联合治疗组患者的评分低于高压氧疗组,差异有统计学意义(P<0.05);高压氧疗组、联合治疗组患者的脑血流量高于常规治疗组,差异有统计学意义(P<0.05);联合治疗组的神经功能评分低于高压氧疗组,差异有统计学意义(P<0.05);联合治疗组的脑血流量高于高压氧疗组,差异有统计学意义(P<0.05)。结论高压氧与尼莫地平联合治疗能显著改善颅脑损伤所致脑功能障碍的神经功能缺损评分及脑血流量,促进患者神经功能的恢复。
Objective To study the effect of hyperbaric oxygen combined with nimodipine in the treatment of cerebral dysfunction resulted from traumatic brain injury. Methods We retrospectively collected and analyzed the data of 124 patients with cerebral dysfunction induced by traumatic brain injury, admitted to the Neurosurgery Department during February 2011 to February 2014. All the patients were divided into the traditional treatment group （n=45）, the traditional treatment with hyperbaric oxygen group （HBO group, n=40） and the traditional treatment with nimodipine and hyperbaric oxygen group （integrated group, n=39）. The differences among the three groups in neurological injury severity evaluated by National Institute of Health Stroke Scale and the cerebral blood flow were recorded and analyzed at three time points （before the treatment, 2 and 4 weeks after treatment）. Results There was no significant difference in neurological injury severity and cerebral blood flow among these three groups before treatment （P 〉 0.05）. Evaluated at 2 and 4 weeks after treatments, the neurological injury severity of HBO group and integrated group were significantly less than the traditional treatment group （P〈 0.05）; the neurological severity score of integrated group was significantly lower than the HBO group （P 〈 0.05）; the cerebral blood flow of HBO group and integrated group were significantly higher than the traditional treatment group （P 〈0.05）; and the cerebral blood flow of integrated group was significantly higher than the HBO group （P 〈 0.05）. Conclusion The combination therapy of hyperbaric oxygen combined with nimodipine is effective in the treatment of cerebral dysfunction induced by traumatic brain injury, because of its attenuation of neurological injury severity and increase of cerebral blood flow.
出处
《华西医学》
CAS
2015年第6期1015-1018,共4页
West China Medical Journal
关键词
高压氧
尼莫地平
颅脑损伤
脑功能障碍
Hyperbaric oxygen
Nimodipine
Traumatic brain injury
Cerebral dysfunction
