摘要
目的分析慢性淋巴细胞白血病(CLL)患者的免疫表型特点及其与临床特征的关系。方法采用流式细胞术检测45例CLL患者外周血或骨髓CD5、CD10、CD19、CD20、CD22、CD23、FMC7、CD38及ζ链相关蛋白70(ZAP-70)的表达。结果45例患者CD5、CD19、CD20、CD22、CD23、CD38和ZAP-70阳性表达率分别为91.1%、100%、100%、73.3%、93.3%、35.6%和40.0%;ZAP-70+CD38+/ZAP-70-CD38-阳性表达率高于ZAP-70+CD38-/ZAP-70-CD38+(80.0%vs.20.0%)(P<0.05)。ZAP-70、CD38表达与Binet分期、化疗有效率具有显著相关性(P<0.01)。结论 ZAP-70和CD38表达是CLL预后判断的重要指标。
Objective To investigate the immunophenotyping characteristics of chromic lymphocytic leukemia（CLL） and its relationship with clinical features .Methods The expressions of CD5 ,CD10 ,CD19 ,CD20 ,CD22 ,CD23 ,FMC7 ,CD38 and ζ‐chain‐associated protein 70 （ZAP‐70 ） in peripheral blood and bone marrow of 45 patients with CLL were detected by flow cytometry .Results The positive rates of CD5 ,CD19 ,CD20 ,CD22 ,CD23 ,CD38 and ZAP‐70 in 45 patients were 91.1% , 100% ,100% ,73.3% ,93.3% ,35.6% and 40.0% ,respectively .The positive rate of ZAP‐70＋CD38＋ /ZAP‐70-CD38- was higher than that of ZAP‐70＋ CD38- /ZAP‐70- CD38＋ （80.0% vs .20.0% ） （P〈0 .05） .Both ZAP‐70 and CD38 expressions were significantly correlated with Binet stage and response rate of chemotherapy （P〈0 .01） .Conclusion ZAP‐70 and CD38 expressions are important indicators for predicting the prognosis of patients with CLL .
出处
《江苏医药》
CAS
2015年第12期1404-1406,共3页
Jiangsu Medical Journal
