期刊文献+

Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively 被引量:2

Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively
原文传递
导出
摘要 INTRODUCTIONAccording to the demographics, the world population over 60 years will double from 605 million to 2 billion people between 2000 and 2050. Aging is a complex process in which the organism and its ability to respond to external stresses become progressive decline. INTRODUCTIONAccording to the demographics, the world population over 60 years will double from 605 million to 2 billion people between 2000 and 2050. Aging is a complex process in which the organism and its ability to respond to external stresses become progressive decline.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第12期1671-1678,共8页 中华医学杂志(英文版)
基金 This work was supported by grants from the National I Natural Science Foundation of China (No. 20971063) and doctoral scientific research funds (No. 318051315).
关键词 Aging-related Disease DEACETYLASE Hypoxia Inducible Factor-1α NAD+ Peroxisome Proliferator-activated Receptor-γ Coactivator- SIRTUINS Aging-related Disease Deacetylase Hypoxia Inducible Factor-1α NAD+ Peroxisome Proliferator-activated Receptor-γ Coactivator- 1α Sirtuins
  • 相关文献

参考文献83

  • 1Haigis MC, Yankner BA. The aging stress response. Mol Cell 2010;40:333-44. 被引量:1
  • 2Haigis MC, Guarente LP. Mammalian sirtuins Emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006;20:2913-21. 被引量:1
  • 3Finley LW, Haigis MC. Metabolic regulation by SIRT3: Implications for tumorigenesis. Trends Mol Med 2012; 18:516-23. 被引量:1
  • 4Giralt A, Villarroya F. SIRT3, a pivotal actor in mitochondrial functions: Metabolism, cell death and aging. Biochem J 2012;444:1-10. 被引量:1
  • 5Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, et al. trans-( - j-e- Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J Bioi Chem 2012;287:24460-72. 被引量:1
  • 6Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010;464:121-5. 被引量:1
  • 7Komlos D, Mann KD, Zhuo Y, Ricupero CL, Hart RP, Liu AY, et al. Glutamate dehydrogenase I and SIRT4 regulate glial development. Glia 2013 ;61 :394-408. 被引量:1
  • 8Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, et al. SlRT6 promotes DNA repair under stress by activating PARPI. Science 2011;332:1443-6. 被引量:1
  • 9Mathias RA, Greco TM, Oberstein A, Budayeva HG, Chakrabarti R, Rowland EA, et al. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell 2014;159:1615-25. 被引量:1
  • 10Laurent G, German NJ, SahaAK, de BoerVC, Davies M, Koves TR, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell 2013;50:686-98. 被引量:1

同被引文献2

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部