摘要
目的:探讨帕金森病合并快速动眼期异态睡眠(RBD)与认知功能障碍之间的关系。方法:收集2012年5月至2014年11月就诊于我院神经内科的54例帕金森病患者,其中帕金森病合并RBD组(PD-RBD组)25例,未合并RBD组(PD-NRBD组)29例,另收集社区健康对照组21例。所有受试者均完成2夜整夜视频多导睡眠监测、统一帕金森病量表I(UP-DRSI)、Hoehn-Yahr分期、蒙特利尔认知评估量表(Mo CA)、爱泼沃斯思睡量表(ESS)的评测。结果:1PD-RBD组注意力与计算力、视空间及执行功能、延迟记忆的得分明显低于PD-NRBD组和健康对照组,差异有统计学意义(均P<0.05);2PD-RBD组和PD-NRBD组睡眠效率较健康对照组低,合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及不宁腿综合征发病率高,差异有统计学意义(P<0.05);3PD-RBD组和PD-NRBD组间睡眠效率及其他睡眠合并症差异无统计学意义(P>0.05)。结论:帕金森病患者合并RBD与认知功能障碍相关,RBD可以作为帕金森病患者认知功能障碍的预测因素。
Objective： To investigate the correlation between rapid-eye-movement sleep behavior disorder（RBD） and the cognitive impairment in patients with Pakinson disease（PD）. Methods： Fifty-four patients with Parkinson disease were enrolled from Neurology Department of Lishui Central Hospital from 2012 to 2013（25 PD-RBD cases and 29 PD-NRBD cases）, with 21 healthy participants as the control group. Full-night videopolysomnography（v PSG） for two nights, Unified Parkinson Disease Rating Scale（UPDRS-III） Questionaire, Hoehn-Yahr stage criteria, Montreal Cognitive Assessment（Mo CA） and The Epworth Sleepiness Scale（ESS） were performed on all study participants. Results： The score for attention and calculation, visual-spatial and its congitive function, delayed memory in PD-RBD group were all significantly lower than that in PD-NRBD group and control group（P〈0.05）. Sleep efficiency in both PD-RBD and PD-NRBD group were lower than that in control group, and often accompanied by obstructive sleep apnea-hypopnea syndrome and restless leg syndrome（P〈0.05）. There was no statistical significant difference between the two PD groups（P〉0.05）. Conclusion： Parkinson disease patients combined with RBD are correlated with cognitive dysfunction. RBD can be used as a predictor for cognition impairment in Parkinson disease.
出处
《温州医学院学报》
CAS
2015年第6期434-436,共3页
Journal of Wenzhou Medical College
关键词
帕金森病
睡眠障碍
认知功能障碍
Parkinson＇s disease
sleep disorders
cognitive impairment
