摘要
目的比较帕珠沙星和左氧氟沙星治疗老年患者合并葡萄球菌下呼吸道感染的疗效和耐药性。方法选择2011年7月至2013年8月重庆医科大学附属第一医院第一分院收治的葡萄球菌下呼吸道感染老年患者194例,分为帕珠沙星治疗组和左氧氟沙星对照组。对葡萄球菌下呼吸道感染患者分离株进行耐药率分析,并比较其耐药率。采用全自动细菌鉴定仪VITEK系统对感染的细菌作鉴定,并进行药敏试验。结果帕珠沙星治疗组总有效率高于左氧氟沙星对照组(93.8%vs.83.5%,χ2=5.127,P<0.05)。葡萄球菌属对帕珠沙星和左氧氟沙星耐药率分别为16.5%和41.7%(χ2=29.979,P<0.01)。其中金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌对帕珠沙星的耐药率均明显低于左氧氟沙星(P<0.05);人葡萄球菌、其他葡萄球菌对帕珠沙星的耐药率与左氧氟沙星比较,差异无统计学意义(P>0.05)。两组的不良反应发生率均比较低,差异无统计学意义(P>0.05)。结论帕珠沙星对老年葡萄球菌下呼吸道感染治疗疗效优于左氧氟沙星,且耐药性较低,值得临床重视。
Objective To compare the effect and drug resistance of pazufloxacin and levofloxaein in the treatment of of lower respiratory tract staphylococci infection in elderly. Methods From July 2011 to August 2013,194 cases of elderly patients diagno- sised with staphylococcus infection of the lower respiratory tract in our hospital were divided into pazufloxacin group and levofloxa- cin group. The diffusion method of drug sensitivity test of were performed in patients with staphylococcal infection of the lower re- spiratory tract,and compared the drug resistance rate. The infected bacteria were identified by the fully automatic VITEK system. The susceptibility test was determined by MIC method and K-B disk diffusion method respectively. Results The total effectiveness in levofloxacin group was 83.5%, and 93.8% in pazufloxacin group, the difference was statistically significant （χ2 = 5. 127, P〈 0.05）. The staphylococcus drug resistance rate of pazufloxacin was 16.5 %, and 41.7 % in levofloxacin, there was significant differ- ence between two groups （χ2 = 29. 979, P〈 0.01）. Thestaphylococcus aureus, staphylococcus epidermidis, Staphylococcus haemo- lyticus resistant rate in pazufloxacin group was significantly lower than those of levofloxacin group（P〈0.05） ;but there was no sig- nificant difference on the resistance rate and levofloxacin pazufloxacin in the aspect of Staphylococcus and other Staphylococcus （P〉0.05）. The adverse reaction of pazufloxacin and levofloxacin group were both low（P〉0.05）. Conclusion The effect of pazu- floxacin in the treatment of staphylococcal infection of the lower respiratory tract in elderly is better than levofloxacin, and the re- sistance is low, it is worthy of attention.
出处
《重庆医学》
CAS
北大核心
2015年第20期2774-2775,2779,共3页
Chongqing medicine
关键词
葡萄球菌
帕珠沙星
氧氟沙星
呼吸道感染
耐药率
staphylococcus
pazufloxacin
ofloxacin
respiratory tract infection
drug resistance rate
