摘要
目的探讨孕妇血浆中的胎盘生长因子（PLGF）与子痫前期妊娠结局的关系。方法采用前瞻性研究方法 ,纳入我院2013年2月至2014年3月间产科门诊以及住院部收治的28~32周的准备行阴道分娩孕妇542例,其中正常产妇450例,65例胎儿过小,25例子痫前期（轻度18例,重度7例）,2例死胎。对纳入的孕妇留取血液标本进行分析,入组孕妇每月进行一次体格检查以及量表分析。血液标本经过离心后分析PLGF含量及其比值,应用Logistic回归分析方法分析其与妊娠结局之间的联系。结果正常孕妇组中的血浆以及尿液中的PLGF水平较其余组明显升高（P〈0.05）,其次依次为胎儿过小组、轻度子痫前期组、重度子痫前期组以及死胎组。各组孕妇血浆中PLGF指标与尿液中变化相似,均可以反映病情的严重程度。血浆的PLGF水平均较尿液PLGF水平明显升高,差异均有统计学意义（P〈0.01）。结论孕妇血浆以及尿液中的PLGF水平可以很好地反映子痫前期的病情严重程度,对相关指标进行检测可以预测子痫前期的发生发展。
Objective To explore the relationship between placenta growth factor（PLGF） and pregnancy outcome of preeclampsia of pregnant women with preeclampsia. Methods 542 cases of pregnant women with scheduled vaginal delivery in our hospital from February2013 to March 2014 were selected, including 450 cases of normal puerpera, 65 cases of small fetus, 25 cases of preeclampsia（18 cases of mild and 7 cases of severe）, and 2 cases of dead fetus. The blood preparations of all cases were analyzed, and physical examination and scale analysis of all cases were taken per month. The PLGF content and ratio were analyzed, and the relationship with pregnant outcome was analyzed by Logistic regression analysis. Results The PLGF levels in plasma and urine of normal puerpera group were the highest compared with other groups（P 0.05）, followed by small fetus group, mild preeclampsia group, severe preeclampsia group and dead fetus group. The PLGF levels in plasma and urine of each group had similar trends; both could reflect the severity of condition. The PLGF levels in plasma were significantly higher than those in urine（P 0.01）. Conclusions The PLGF levels in plasma and urine of pregnant women can reflect the severity of preeclampsia, and the detection of related indexes can predict the development of preeclampsia.
出处
《临床医学工程》
2015年第7期891-892,共2页
Clinical Medicine & Engineering
关键词
子痫前期
妊娠结局
胎盘生长因子
Preeclampsia
Pregnancy outcome
Placenta growth factor
