摘要
目的：了解海南地区女性人群高危型人乳头瘤病毒（HR-HPV）的感染率和亚型分布情况。方法：采用导流杂交基因芯片技术,对妇科门诊14 335例就诊者的宫颈脱落细胞标本进行HPV分型检测,并分析检测结果。结果：本地区女性HR-HPV感染率31.36%;由高到低排列依次为52型（22.75%）、16型（20.82%）、58型（15.01%）、18型（7.59%）、33型（6.49%）、68型（5.75%）、31型（5.18%）、39型（3.49%）、56型（3.12%）、66型（2.67%）、59型（2.56%）、35和51型分别（1.75%）、45型（1.07%）;在各年龄段之间,HPV感染率不同,差异有统计学意义;以单一亚型感染为主,占84.61%;三种以上的多重感染在〈30岁和〉50岁年龄段与31~50岁年龄段之间存在差异,有统计学意义。结论：本地区高危型HPV感染率处于较高水平;占半数以上的前三位亚型依次是52、16、58型;随着年龄的增大,HPV感染率有增加的趋势;三种亚型以上的多重感染为〈30岁和〉50岁年龄段者居多。
Objective： To investigate the high-risk（HR） HPV infection rate and the distribution of HPV genotypes in Hainan area. Methods： Cervical ceils samples of 14 335 gynecological outpatients were examined with flow-through hy- bridization and gene chip techniques and the results were analyzed. Results： The rate of HR-HPV infection was 31.36% in all cases. The sequence of infection rate from high to low was type 52（22.75% ） ,type 16（20.82% ） ,type 58 （ 15. 01% ） ,type 18（7. 59% ） ,type 33（6.49% ） ,type 68（5.75% ） ,type 31 （5.18%） ,type 39（3.49% ） ,type 56（3.12% ）, type 66 （2. 67 % ） ,type 59 （2.56%） ,type 35 and type 51 （ 1.75 % ） and type 45 （ 1.07 % ）. HT-HPV infection rates were significantly different between various age groups. The single type infection was the predominant infection type and accoun- ted for 84.61% of all HPV infections. The multi-infection consisted of more than three HPV types showed statistically sig- nificant difference between the age group of 〈 30 years , 〉 50 years and 31 ~ 50 years. Conclusion： HR-HPV infection rate is at a relatively high level in our area. The top three HR-HPV subtypes include type 52,16 ,and 58, which acount o- ver half of all HR-HPV subtypes ; HR-HPV infection rate increases along with the growth of age. The rate of multi-infection consisted of more than three HPV types is higher in 〈 30 years and 〉 50 years age groups.
出处
《肿瘤预防与治疗》
2015年第3期140-143,共4页
Journal of Cancer Control And Treatment
关键词
高危型HPV
感染率
亚型分布
导流杂交基因芯片技术
High-risk HPV
Infection Rate
Subtype Distribution
Flow-through Hybridization and Gene Chip Technique
