摘要
【目的】比较壮医莲花针背廊拔罐法、辅舒良鼻喷雾剂以及西替利嗪等治疗变应性鼻炎(AR)的有效性,并对背廊拔罐法的作用机制开展研究。【方法】采用随机序列的生成方法,将200例AR患者按1∶1∶1∶1比例,随机分为壮医莲花针背廊拔罐法组(试验组)、辅舒良组(对照A组)、西替利嗪组(对照B组)和空白对照组,每组各50例。试验组给予壮医莲花针叩刺背廊拔罐法治疗,对照A组给予辅舒良鼻喷雾剂喷鼻治疗,对照B组给予口服西替利嗪片治疗,空白对照组不接受任何治疗,各组疗程均为10 d,停1周后继续第2个疗程,2个疗程后观察各组的临床疗效及对特异性Ig E(S-Ig E)、白三烯(LT)、白细胞介素-4(IL-4)、IL-9 m RNA、干扰素-γ(IFN-γ)、Thl/Th2细胞、Th17细胞因子(IL-17)等的影响。【结果】(1)经2个疗程治疗后,试验组疗效优于各对照组,对照A组和对照B组疗效优于空白对照组(均P<0.05),而对照A组与对照B组比较,差异无统计学意义(P>0.05)。(2)治疗后,各治疗组的S-Ig E、LT、IL-9 m RNA、IL-4、IL-17水平降低,IFN-γ、Th1/Th2水平升高,与治疗前比较差异均有统计学意义(均P<0.05);而空白对照组治疗前后各指标比较,差异均无统计学意义(P>0.05)。治疗后组间比较,试验组对S-Ig E、LT、IFN-γ、Th1/Th2的改善作用优于对照A组和对照B组(均P<0.05)。(3)在研究过程中,各组均未发现不良反应事件发生。【结论】壮医莲花针背廊拔罐法治疗AR疗效确切,其机制可能为抑制S-Ig E、LT、IL-9 m RNA、IL-17的表达,并通过降低Th2、提高Th1细胞因子水平的表达,调节Th1/Th2失衡而发挥作用。
Objective The effectiveness of Zhuang nationality medical lotus needle plus back cupping therapy（Zhuang needle-cupping therapy）, Flixonase aqueous nasal spray and cetirizine tablets in treating allergic rhinitis（AR） was compared for the exploration of the therapeutic mechanism of Zhuang needle-cupping therapy.Methods A total of 200 recruited AR patients were randomly divided into four groups in the proportion of 1：1：1：1. The four groups were Zhuang needle-cupping therapy group, cetirizine group, Flixonase group and blank control group. The blank control group had no medication, and the patients of the other three medication groups were given the corresponding treatment. Ten days constituted one treatment course, and interval between two courses lasted one week. After two courses, the therapeutic effect was evaluated. The changes of specific Ig E（S-Ig E）, leukotriene（LT）, interleukin 4（IL-4）, IL-9 m RNA, interferon gamma（IFN-γ）, Thl/Th2 cells,and Th17 cytokine（IL-17） were observed before and after treatment. Results（1） After two treatment courses,Zhuang needle-cupping therapy group had better therapeutic effect than cetirizine group, Flixonase group and blank control group, and the therapeutic effect of cetirizine group and Flixonase group was better than the blank control group（P〈0.05）. However, the therapeutic effect of cetirizine group was similar to that of Flixonase group（P〉0.05）.（2） After treatment, the levels of S-Ig E, LT, IL-9 m RNA, IL-4 and IL-17 were decreased, and IFN-γ and Th1/Th2 levels were increased in the three medication groups（P〈0.05 compared with those before treatment）. The differences of the laboratory indexes in the blank control group were insignificant before and after treatment（P〉0.05）. The results of inter-group comparison after treatment showed that Zhuang needle-cupping therapy group had better effect on improving S-Ig E, LT, IFN-γ and Th1/Th2 than cetirizine group and Flixonase group（P〈0.05）.（3） During the
出处
《广州中医药大学学报》
CAS
2015年第4期677-682,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:81160465)
广西自然科学基金项目(编号:GXNSFA018310)
广西壮族自治区卫生厅中医药科技专项(编号:GZKZ10-015)
