摘要
目的探讨介入治疗对非小细胞肺癌(NSCLC)患者炎性因子的影响。方法 76例不可切除的NSCLC患者随机分为介入组和静脉化疗组,静脉化疗组给予常规静脉化疗方案,每月化疗1次,连续化疗3次。介入组给予支气管动脉灌注化疗术联合支气管动脉栓塞术,介入治疗每月治疗1次,连续治疗3次。在治疗前1周及第3次治疗后分别采集两组患者静脉血,检测外周血的肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、C反应蛋白(c-reation receptor protein,CRP),降钙素原(procalcitonin,PCT),并进行比较。结果介入组治疗后三种炎症因子明显降低,与术前及静脉化疗组相比,差异具有统计学意义(P<0.05)。介入治疗组有效率72.5%,静脉化疗组38.9%(χ2=8.713,P=0.003),TNF-α、CRP、PCT在治疗后介入组分别为(35.89±19.53)ng/L、(10.36±2.14)mg/L、(2.48±1.51)μg/L,静脉化疗分别为(39.54±17.32)ng/L、(10.31±2.54)mg/L、(2.64±0.94)μg/L。结论介入治疗可以有效降低NSCLC患者炎性因子水平。
Objective To investigate the effects of interventional treatment on inflammatory cytokines in patients with non-small cell lung cancer. Methods A total of 76 patients with non-small lung cancer were randomly divided into interventional treatment group and control group. 36 cases in control group were treated with intravenous chemotherapy. 40 cases in interventional treatment group were treated with BAI（ bronchial arterial infusion） ＋ BAE（ bronchial arterial embolization）. Venous sampling was carried out before treatment and after the third treatment. The of serum CRP（ c-reation protein）,TNF-α（ tumor necrosis factor-α）,PCT（ procalcitonin） of the two groups were compared statistically. Results There were significant differences between the serum concentration changes of the inflammatory factors before and after therapy in every group and in comparison between every two groups（P〈0. 05）. effective rate was 72. 5% in interventional treatment group,38. 9% in control group（ χ2= 8. 713,P = 8. 713）,TNF-α,CRP and PCT were（ 35. 89 ± 19. 53）ng / L,（ 10. 36 ± 2. 14） mg / L,（ 2. 48 ± 1. 51） μg / L in the interventional treatment group respectively,（ 39. 54 ± 17. 32） ng/L,（ 10. 31 ± 2. 54） mg/L,（ 2. 64 ± 0. 94） μg/L in control group respectively. Conclusion The interventional treatment can reduce the level of serum inflammatory factors in Patients with Non-small cell lung cancer.
出处
《中华肺部疾病杂志（电子版）》
CAS
2015年第3期36-39,共4页
Chinese Journal of Lung Diseases(Electronic Edition)
关键词
肺癌
介入治疗
栓塞
静脉化疗
Lung cancer
Interventional treatment
Embolization
Intravenous chemotherapy
