摘要
目的探讨应用实时剪切波弹性成像检测肝脏弹性模量及血清肝纤维化指标与肝脏纤维化相关性研究。方法选取平煤集团总医院诊断为慢性肝病患者68例,均进行血清肝纤维化指标检测,肝脏活检和实时剪切波弹性成像检测,分析肝脏弹性模量值与血清肝纤维化指标及肝脏病理的相关性。结果 G0/G1组中,透明质酸(HA)、Ⅲ型前胶原肽(PCⅢ)、Ⅳ型胶原(ⅣC)及层粘连蛋白(LN)与S5段的弹性值及S6段的弹性值均无相关关系;G2组中,HA与S6段的弹性值呈正相关(r=0.58,P<0.05),S5段则无相关性(P>0.05);PCⅢ与S5、S6段的弹性值呈正相关(r=0.65,P<0.05;r=0.48,P<0.05);ⅣC与S5、S6段的弹性值呈正相关(r=0.71,P<0.01;r=0.55,P<0.05);G3/G4组中,LN与S5段的弹性值呈正相关(r=0.78,P<0.05),与S6段则无相关性(P>0.05);ⅣC与S5段的弹性值呈正相关(r=0.91,P<0.05),与S6段则无相关性(P>0.05);S0/S1组中,HA、PCⅢ、LN、ⅣC与S5段的弹性值及S6段的弹性值均无相关关系;S2组中,HA与S6段的弹性值呈正相关(r=0.54,P<0.05),与S5段则无相关性(P>0.05);PCⅢ与S5、S6段的弹性值呈正相关(r=0.72,P<0.05;r=0.65,P<0.05);ⅣC与S5、S6段的弹性值呈正相关(r=0.66,P<0.05;r=0.52,P<0.05);S3/S4组中,HA、PCⅢ、LN、ⅣC与S5段的弹性值及S6段的弹性值均无相关性。肝组织炎症分级与纤维化分期有显著相关性(r=0.512,P<0.05)。结论实时剪切波弹性成像测得肝脏硬度与血清肝纤维化指标及肝脏病理有较好的相关性,实时剪切波弹性成像可动态监测肝纤维化进展,评估肝纤维化程度。
Objective To explore the application of real-time shear wave elasticity inmaging to detect the liver elastic modulus and serum liver fibrosis indexes and liver fibrosis. Methods In Pingdingshan Coal Group General Hospital 68 patients who were diagnosed as chronic liver disease, were detected the serum indices of liver fibrosis, liver biopsy and SWE test, analyzed the liver elastic modulus ＇values correlated with serum liver fibrosis indexes and liver pathology. Results In group G0/G1, HA, PCIII, LN, IVC and S5 segments of the elastic value and S6 segment of elasticity values were not correlated; in group G2, HA and S6 segments of the elasticity value was positively correlated （r=0.58, P〈0.05）, S5 segment had no correlation （P〉0.05）; PCIII and S5, S6 segment of the elasticity value were positively correlated （r=0.65, P〈0.05, r=0.48, P〈0.05）; 1VC and S5, S6 segment of the elasticity value were positively correlated （r=0.71, P〈0.01, r=0.55, P〈0.05）; in group G3/G4, LN and S5 segments of the elasticity value was positively correlated （r=0.78, P〈0.05）. No correlation was with S6 segment （P〉0.05）; IVC and S5 segment of the elasticity value was positively correlated （r=0.91, P〈0.05）, while no correlation was with S6 segment （P〉0.05）; in group S0/S1, HA, PCIII, LN, IVC and S5 segments of the elastic value and S6 segment of elasticity values were not correlated; S2 in group A, HA and S6 segments of the elasticity valuewas positively correlated （r=0.54, P〈0.05）, S5 segment is no correlation （P〉0.05）; PCIII and S5, S6 segment of the elasticity value were positively correlated （r=0.72, P〈0.05, r=0.65, P〈0.05）; IVC and S5, S6 segments were positively correlated with the value （elastic r-~.66, P〈0.05, r=0.52, P〈0.05）; in group S3/S4, HA, PCILI, LN, IVC and S5 segments of the elastic value and S6 segment of elasticity values were not correlated. Grading and fibrosis staging of liver tissue inflammation was significantly correlated （r=0.512, P〈
出处
《中华临床医师杂志（电子版）》
CAS
2015年第11期53-56,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
弹性成像技术
肝炎
乙型
慢性
肝硬化
肝脏病理
相关性
Elasticity imaging techniques
Hepatitis B, chronic
Liver cirrhosis
Liverpathology
Correlation
