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白细胞介素-1β干预下肝细胞生长因子在人牙周膜成纤维细胞中的基因表达研究 被引量:3

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摘要 牙周病是发生在牙周组织的慢性感染性疾病,包括牙龈炎和牙周炎,是人类口腔最常见的疾病之一。周病最初和最重要的病理改变是结合上皮的增殖和根尖迁移以及伴随着牙周袋的形成。而肝细胞生长因子(hepatocyte growth fac-tor,HGF)能够促进上皮细胞的增殖,抑制上皮细胞的凋亡及促进胶原降解,抑制胶原合成,因此其在牙周病发展进程中起着重要的作用。本实验拟通过观察白细胞介素(IL)-1β干预人牙周膜成纤维细胞后,HGF的基因表达情况,探讨HGF在牙周病中的表达及意义,为下一步牙周病的临床治疗以及牙周组织工程学的研究提供理论依据。
出处 《中国药物与临床》 CAS 2015年第6期773-775,共3页 Chinese Remedies & Clinics
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同被引文献37

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