摘要
[目的]为改善黄腐酚水溶性。[方法]采用研磨法,比较黄腐酚与7种环糊精的包合效果。在此基础上,通过单元素试验考察主客体分子比、研磨时间、温度和纯度对黄腐酚-HP-β-CD包合物包合效果的影响,以随机质心优化设计试验优化黄腐酚-HP-β-CD包合物的制备工艺。[结果]黄腐酚与羟丙基-β-环糊精(HP-β-CD)的包合效果最好,即在主客分子比50∶1,包合温度42℃,研磨时间37 min的条件下,黄腐酚-HP-β-CD包合物的包合率达99%以上。[结论]黄腐酚-HP-β-CD包合物改善黄腐酚的水溶性,拓宽黄腐酚的应用范围。
[Objective] The purpose was to improve the water-solubility of xanthohumol. [Method]The adduction effects of xanthohumol were compared using seven kinds of cyclodextrins. On the basis of above results,the influences of the host-guest molecular ratio,triturate time,adduction temperature and purity on the adduction effect of xanthohumol-HP-β-CD were evaluated by single factor experiment in grinding methods.And the inclusion process was further optimized by the methods of random centroid optimization. [Result]There was a best adduction effect when maxed xanthohumol with HP-β-CD,and the inclusion rate of xanthohumol-HP-β-CD clathrate was up to 99% when the host-guest molecular ratio was 50∶ 1,the adduction temprature was 42 ℃,and the triturate time was 37 min. [Conclusion]Xanthohumol-HP-β-CD improved the water-solubility of xanthohumol and widened its application.
出处
《安徽农业科学》
CAS
2015年第20期23-26,共4页
Journal of Anhui Agricultural Sciences
关键词
黄腐酚
环糊精
包合工艺
Xanthohumol
Cyclodextrin
Inclusion process
