摘要
目的 事件相关电位（event related potential,ERP）研究一直是神经电生理研究的热点.越来越多的研究表明ERP可以有效反映抑郁症患者的认知功能,评估其自杀风险.本文综述了ERP相关成分与抑郁症自杀的相关研究,并在此基础上对ERP在抑郁症研究中的应用局限进行初步探讨,以及对以后的发展进行展望.方法 检索2013年6月～2015年1月PUBMED数据库,外文医学信息资源检索平台,CNKI,万方数据库等数据库的相关文章.检索式TI：[depression OR affective disorder] AND[suicide OR suicidal] All field：event related potential.摘要阅读,缩小文献范围.了解实验设计思路,如：样本为伴有自杀意念和（或）行为的抑郁症患者,电位诱发方式,ERP相关成分检测方法等.最终所得文献英文43篇,中文15篇.阅读全文,保留近5年有关抑郁症自杀相关文献.结果 最终确定34篇相关文章,其中3篇中文文章.结论 伴有自杀意念和（或）行为的抑郁症患者存在认知功能障碍,ERP相关成分如：P300、CNV、MMN等存在异常,N400尚未发现异常.本文仅从抑郁症自杀的角度综述了相关研究中ERP的特征,对其他精神疾病的ERP相关研究暂位列其中,有待今后完善。
Objective ERP research has always been the hot spot of the n～ve electrophysiology research.A gTowing body of research suggests that ERP can effectively reflect the cognitive function in patients with depression,evaluate the risk of suicide.This paper reviews the ERP related components with depression and related research.On the basis of the application of ERP in the depression research discusses limitations and prospects on the later development.Methods The articles were retrievaled from databases,such as P UBMED,Foreign medical information resources retrieval platform,CNKI,Wanfang database,ect,from 2013-06 to 2015-01.Index strategy TI：TI：[depression OR affective disorder] AND [suicide OR suicidal] All field：event related potential.Reading and narrowing the scope of the articles,we should understand the experimental design,such as Sample company have suicidal ideation and （or） behavior of patients with depression.Potential induced way,ERP related component detection method,etc.The articles included 43 in English and 15 in Chinese.Read the full text and retain nearly five years about depression and related literature.Results Eventually,the article includes 34 articles and 3 of in Chinese.Conclusion Associated with suicidal ideation and （or） behavior of the existing cognitive dysfunction in patients with depression,ERP related components such as：abnormal P300 and CNV,MMN.N400 have not found abnormal.This article only from the Angle of depression and related research are reviewed in this paper the characteristics of ERP,ERP of other mental illnesses among related research,and to be perfect in the future.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2015年第6期565-568,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
黑龙江省自然科学基金项目（D2004-54）
黑龙江省博士后科研启动金资助项目（LBH-Q12031）
关键词
抑郁症
自杀
事件相关电位
Depression
Suicide
Event related potential
