摘要
目的分析神经内科门诊阿尔茨海默病患者精神行为症状治疗效果。方法选取在我院门诊就诊的伴精神行为症状的阿尔茨海默病患者80例,随机分为喹硫平组和利培酮组各40人,喹硫平组服用喹硫平;利培酮组服用利培酮观察所有患者治疗前后BEHAVE-AD、治疗效果、不良反应出现情况进行记录和分析。结果两组治疗前、治疗后2周BEHAVE-AD与疗效分级差异无统计学意义,P=0.8829,但是治疗后4周,喹硫平组BEHAVE-AD(10.5±5.6)小于利培酮组(12.8±4.3),差异有统计学意义,P=0.0427;喹硫平组出现锥体外系反应比率(5.00%)小于利培酮组(25.00%),差异有统计学意义,P=0.0123。结论喹硫平对于控制阿尔茨海默病患者精神行为症状的短期疗效优于利培酮,安全性也更优,值得推广。
Objective To analyze therapeutic effects of psychological and behavioral symptoms for Alzheimer＇s Disease patients in neurology outpatient department. Methods 80 outpatients with Alzheimer＇s Disease and psychological and behavioral symptomswere chosen and randomly divided to risperidone groupand quetiapine.Their BEHAVE- AD,therapeutic effects,side effects before and after treatment were noted and analysed. Results Before and 2- week after treatment BEHAVE- AD and therapeutic rank of two groups were not significantly different,P = 0. 8829,but 4- week after treatment BEHAVE- AD of quetiapine group（ 10. 5 ± 5. 6） was less risperidone group（ 12. 8 ± 4. 3）,whose difference was significant,P = 0. 0427. Extrapyramidal system reaction ratios of quetiapine group（ 5. 00%） was less than risperidone group（ 25. 00%）,whose difference was significant,P = 0. 0123. Conclusion Quetiapine is better than risperidone in short therapeutic effects to control psychological and behavioral symptoms for Alzheimer＇s Disease,and security of quetiapine is also better.
出处
《国际精神病学杂志》
2015年第3期48-51,共4页
Journal Of International Psychiatry
关键词
阿尔茨海默病
门诊
精神行为症状
治疗
AD
Outpatient
Behavioral and psychological symptom
Treatment
