摘要
目的探讨坎地沙坦治疗高原地区藏族慢性收缩性心力衰竭患者的效果。方法将526例藏族慢性收缩性心衰患者随机分为治疗组252例和对照组274例,2组均在治疗原发病的基础上给予常规强心、利尿、扩血管类药物,对照组加用依那普利,治疗组加用坎地沙坦。治疗8周后,比较2组间的心功能改善程度、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)及血压的差异。结果治疗组的显效率(45.2%)、有效率(52.8%)、无效率(2.0%)与对照组的显效率(44.9%)、有效率(52.9%)、无效率(2.2%)比较差异无统计学意义;治疗后,2组的LVEF均较治疗前增高,LVEDD、血压均降低,差异有统计学意义;而2组间比较差异均无统计学意义。结论依那普利和坎地沙坦在治疗高原地区藏族慢性收缩性心力衰竭的效果方面无明显差异。
Objective To investigate the curative effect of Candesartan on chronic systolic heart failure in Tibetan pla-teau. Methods A total of 526 patients with chronic systolic heart failure were divided into two groups randomly （Treatment group N=252;Control group N=274）. Regular medicines, such as cardiac, diuretic and vasodilator drugs , are given to pa-tients in both groups according to their primary underlined diseases. Additionally, enalapril is added in control group, while candesartan is added in treatment group. Improvement of cardiac function, LVEF, LVEDD and blood pressure were compared between these two groups after 8 weeks. Results There was no significant difference in effective rate （i.e., 45.2%in treat-ment group and 44.9% in control group, respectively）, efficiency rate （i.e. 54.8% in treatment group and 55.1% in control group, respectively） and inefficiency rate （i.e. 2.0%in treatment group and 2.2%in control group, respectively） between treat-ment and control groups . After treatment, LVEF in the two groups are all improved, while LVEDD and blood pressure both de-creased with statistical significance. However, the difference between the two groups is not significant. Conclusion No sta-tistical difference was found in curative effect on chronic systolic heart failure in Tibetan Plateau between two groups.
出处
《天津医药》
CAS
2015年第6期666-668,共3页
Tianjin Medical Journal
基金
西藏昌都地区重点科技项目(昌地财农指[2010]114号)
关键词
藏族
高原病
依那普利
心力衰竭
坎地沙坦
Zang nationality
altitude sickness
enalapril
heart failure
candesartan
