摘要
目的:研究急性心肌梗死(心梗)患者,在接受急诊经皮冠状动脉介入治疗(PCI)术前以及术后给予前列地尔治疗,观察患者尿素氮、血肌酐以及血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平的变化。方法:收集2011-2013年急性ST段抬高型心梗患者共60例,随机分为治疗组和对照组,两组在行PCI前均给予阿司匹林300mg和氯吡格雷600mg口服。治疗组在PCI前加用前列地尔10μg静脉推注。PCI术后两组均给予常规治疗,治疗组加用前列地尔10μg静脉推注,每天1次,连续5d。分析两组术前,术后6,24,72h尿素氮、血肌酐以及NGAL的变化。结果:术前两组的尿素氮、血肌酐以及NGAL水平没有明显差异(P>0.05)。术后6h,两组NGAL水平有所上升,对照组术后24,72h各指标均升高,差异有统计学意义,治疗组术后24h各指标有一定程度升高,但72h各指标与术前比较,差异无统计学意义。结论:使用前列地尔注射液对行急诊PCI术的急性心梗患者的肾功能有一定保护作用。
Objective： To observe the changes of blood urea nitrogen（BUN） and serum creatinine （SCR） and serum NGAL in patients with acute myocardial infarction when they accept treatment of al- prostadil injection before and after PCI. Methods： Sixty patients with AMI in our hospital from 2011 to 2013 were randomly divided into two groups： control group（n=30） and treatment group （n=30）. Both of two groups received Aspirin 300mg and Clopidogrel 600mg before PCI. The treatment group received intravenous injections of 10 μg alprostadil before PCI and also after PCI once a day for 5 days. The changes of BUN, SCR and NGAL were recorded at different time points. Results： There was no difference between two groups in the levels of BUN, SCR and NGAL. After PCI,there was an increase in the levels of BUN,SCR and NGAL, but more obvi- ous in the control group. There was on difference in the treatment group between 72 h after PCI and before PCI. Conclusion： Alprostadil injection has a protective effect on renal function in pa- tients with acute myocardial infarction who accept PCI.
出处
《武汉大学学报（医学版）》
CAS
2015年第4期592-594,共3页
Medical Journal of Wuhan University
