摘要
目的探讨补肾调肝法治疗老年期抑郁的临床疗效。方法以肾虚肝郁型老年期抑郁患者为研究对象,分别采用补肾调肝汤(自拟)加减干预方案及西药盐酸舍曲林口服干预方案,观察期为12周,通过汉密尔顿抑郁量表减分率及中医证候疗效指数判断补肾调肝法对肾虚肝郁型老年期抑郁的临床疗效。结果治疗12周前后补肾调肝汤和盐酸舍曲林组,在汉密尔顿抑郁量表、汉密尔顿焦虑量表、匹兹堡睡眠质量指数及肾虚肝郁量表均有下降(P<0.01);其中对于汉密尔顿抑郁量表减分率的改善补肾调肝组不如盐酸舍曲林组,但对于汉密尔顿焦虑量表、匹兹堡睡眠质量指数及肾虚肝郁量表的减分率优于盐酸舍曲林组(P<0.01)。结论补肾调肝法治疗老年期抑郁症具有良好的临床疗效,且具有改善睡眠及躯体症状的作用。
Objective To investigate the clinical efficacy of Tonifying Kidney and Supplementing Liver therapy for senile depression. Methods Bushen tiaogan（ Tonifying Kidney and Supplementing Liver） Decoction,along with Western medicine and sertraline hydrochloride treatment,has been used for 12 weeks on senile depression patients of kidney deficiency and liver qi stagnation type. Clinical efficacy was assessed by the Hamilton Depression Scale（ HAMD） score index and the rate of TCM syndrome curative effects. Results After 12 weeks of treatment,the index of HAMA,HAMD,PSQI as well as the scale of kidney deficiency and liver qi stagnation were reduced in both groups（ P〈0. 01）. Although the rate of reduction of HAMD in Bushen tiaogan Decoction group was not better than that in sertraline hydrochloride group,the rate of reduction of HAMA,PSQI,kidney deficiency and liver qi stagnation scale in Bushen tiaogan Decoction group was not better than that in sertraline hydrochloride group（ P〈0. 01）.Conclusion Bushen tiaogan therapy has good clinical efficacy for the treatment of senile depression,and it can also improve the quality of sleep and relieve somatic symptoms.
出处
《环球中医药》
CAS
2015年第4期432-435,共4页
Global Traditional Chinese Medicine
基金
2010年北京中医药大学东方医院院级课题(YJ201002)
2012年教育部博士点新教师类基金(20120013120014)
2013年北京中医药大学科研基金青年教师专项
关键词
老年抑郁症
肾虚肝郁证
盐酸舍曲林
Senile depression
Kidney deficiency and liver qi stagnation syndrome
Sertraline
