期刊文献+

尿液中前列腺癌肿瘤标志物的研究进展 被引量:1

Research Progress in Urinary Biomarker of Prostate Cancer
下载PDF
导出
摘要 前列腺癌是男性泌尿生殖系统中最常见的肿瘤之一,其发病率呈逐年上升趋势。因其起病隐匿,大部分患者很难早期发现治疗,早期诊断对于其治疗及预后具有重要意义,因而寻找早期特异性的前列腺癌诊断方法十分重要。早期诊断对于其治疗及预后具有重要意义。理想的早期诊断前列腺癌的方法应该具有客观的,非侵入性的,高敏感性和特异性,操作简单,费用低廉等特点。前列腺液通过尿道排出,因此尿液有望成为筛查前列腺癌的理想材料。 Prostate cancer is one of the most common tumors of male genitourinary system and the incidence of it is on a rising trend. As its onset is concealed,it is difficult to realize early detection and treatment in most of the patients,while early diagnosis has great significance for the treatment and prognosis,therefore it is very important to look for the specific diagnosis of prostate cancer. The ideal method of early diagnosis of prostate cancer should be objective,non-invasive,with high sensitivity and specificity,simple operation and low cost. Prostate fluid is discharged through the urethra,so the urine is expected to become an ideal material of screening for prostate cancer.
出处 《医学综述》 2015年第12期2174-2177,共4页 Medical Recapitulate
关键词 前列腺癌 标志物 尿液 Prostate cancer Biomarker Urine
  • 相关文献

参考文献38

  • 1Bussemakers MJ,van Bokhoven A,Verhaegh GW,et al.DD3:a new prostate-specific gene,highly overexpressed in prostate cancer[J].Cancer Res,1999,59(23):5975. 被引量:1
  • 2Hessels D,Klein GJ,van Oort I,et al.DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer[J].Eur Urol,2003,44(1):8-15. 被引量:1
  • 3Tosoian JJ,Leob S,Kettermann A,et al.Accuracy of PCA3 measurement in predicting short-term biopsy progression in an active surveillance program[J].J Urol,2010,183(2):534-538. 被引量:1
  • 4Groskopf J,Aubin SM,Deras IL,et al.APTIMA PCA3 molecular urine test:development of a method to aid in the diagnosis of prostate cancer[J].Clin Chem,2006,52(6):1089-1095. 被引量:1
  • 5Marks LS,Fradet Y,Deras IL,et al.PCA3 molecular urine assay for prostate cancer in men undergoing repeat biopsy[J].Urology,2007,69(3):532-535. 被引量:1
  • 6Rubio-Briones J,Femandez-Serra A,Ramirez M,et al.Outcomes of expanded use of PCA3 teseting in a Spanish population with clnical suspicion of prostate cancer[J].Actas Urol Esp,2011,35(10):589-596. 被引量:1
  • 7刘龙亚,温端改,何军,侯健全,岑建农,浦金贤.外周血与尿PCA3基因表达和尿PCA3评分在前列腺癌诊断中的意义[J].中华泌尿外科杂志,2012,33(4):278-281. 被引量:21
  • 8Tombal B,Andriole GL,de la Taille A,et al.Clinical judgment versus biomarker prostate cancer gene 3:which is best when determining the need for repeat prostate biopsy?[J].Urology,2013,81(5):998-1004. 被引量:1
  • 9Liss MA,Santors R,Osann K,et al.PCA3 molecular urine assay for prostate cancer:association with pathologic features and impact of collection protocols[J].Word J Urol,2011,29(5):683-688. 被引量:1
  • 10Tomlins SA,Rhodes DR,Perner S,et al.Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer[J].Science,2005,310(5748):644-648. 被引量:1

二级参考文献31

  • 1陈占国,陶志华,陈晓东,李澄棣,余志贤,李湘斌,杨建荣.前列腺癌特异性基因DD3在前列腺癌患者外周血中表达的意义[J].中华泌尿外科杂志,2005,26(12):806-808. 被引量:5
  • 2翁志梁,余凯远,毛晓露,陶志华,陈晓东,吴秀玲,胡元平,王思齐,李澄棣,陈占国.外周血差异显示编码3mRNA定量检测在前列腺癌患者诊断与治疗监测中的初步应用[J].中华医学杂志,2006,86(41):2911-2915. 被引量:9
  • 3BALK S P. Androgen receptor as a target in androgen- independent prostate cancer [ J ] . Urology, 2002, 60(3 Suppl 1): 132-139. 被引量:1
  • 4CULIG Z, KLOCKER H, BARTSCH G, et al. Androgen receptors in prostate cancer [ J ] . J Urol, 2003, 170(4 Pt 1): 1363-1369. 被引量:1
  • 5GELMANN E P. Molecular biology of the androgen receptor [ J ]. J Clin Oncol, 2002, 20(13): 3001-3015. 被引量:1
  • 6HEINLEIN C A, CHANG C. Androgen receptor (AR) coregulators: an overview [ J ] . Endocr Rev, 2002, 23(2): 175-200. 被引量:1
  • 7CHMELAR R, BUCHANAN G, NEED E F, et al. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer [ J ] . Int J Cancer, 2007, 120(4): 719-733. 被引量:1
  • 8HUANG C Y, BELIAKOFF J, LI X, et al. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes [ J ] . Mol Endocrinol, 2005, 19(12): 2915-2929. 被引量:1
  • 9THOMAS C E, SEXTON W, BENSON K, et al. Urine collection and processing for protein biomarker discovery and quantification [ J ] . Cancer Epidemiol Biomarkers Prey, 2010, 19(4): 953-959. 被引量:1
  • 10BETSOU F, BARNES R, BURKE T, et al. Human biospecimen research: experimental protocol and quality control tools [ J ] . Cancer Epidemiol Biomarkers Prey, 2009, 18(4): 1017-1025. 被引量:1

共引文献23

同被引文献33

  • 1Center MM,Jemal A,Lortet-Tieulent J,et al.International Variation in Prostate Cancer Incidence and Mortality Rates [J] . European Urology,2012,61 (6): 1079-1092. 被引量:1
  • 2Jiang N,Zhu S,Chen J,et al.A-methylacyl-CoA racemase(AMACR)and prostate-cancer risk:a meta-analysis of 4,385participants [J] .PlosOne,2013,8(10):394-397. 被引量:1
  • 3ED Crawford,JW Moul,KO Rove,et al.Prostate-specific antigenl. 5-4.0 ng/mL:a diagnostic challenge and danger zone [J] .Bju International,2011,108 ( 11): 1743-1749. 被引量:1
  • 4Strittmatter F,StieberP,Nagel D,etal.Detection ofprostate cancer with complexed PSA and complexed/total PSA ratio:is there any advantage? [J] .European Journal of Medical Research,2011,16(10):445-50. 被引量:1
  • 5Stavros Sfoungaristos,Petros Perimenis.PSA density is superior than PSA and Gleason score for adverse pathologic features prediction in patients with clinically localized prostate cancer [J] .CanLrolAssocJ,2012,6(1):46-50. 被引量:1
  • 6Abrate A,Lazzeri M,Buffi N,et al.P2psa and derivatives (%p2psa and phi)accurately predict prostate cancer in obese menfrom a multicenter prospective european study [J] .J Urol,Journal of Urology,2014,191 (4):e859. 被引量:1
  • 7Fossati N,Buffi NM,Haese A,et al.Preoperative prostate- spe-eific antigen isoform p2psa and its derivatives,%p2psa andprostate health index,predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer: tl esults from amulticentric European prospective study [J] . Eur Urol,2015,68(1): 132-138. 被引量:1
  • 8Lazzeri M,Abrate A,Lughezzani G,et al.Relationship of chro-nic histologic prostatic inflammation in biopsy specimens withserum isoform [-2] proPSA(p2PSA),%p2PSA,and prostatehealth index in men with a total prostate-specific antigen of 4-10ng/mL and normal digital rectal examination [J] .Urology,2014,83(3):606-12. 被引量:1
  • 9Lazzeri M,Haese A,Abrate A,et al.Clinical performance of serum prostate-specific antigen isoform [2] proPSA (p2PSA)and its derivatives,%p2PSA and the prostate health index(PHI),in men with a family history of prostate cancer:Results from a multicentre European study, the Pr ROMETHEUS project [J] .BJU Int,2013,112(3):313-321. 被引量:1
  • 10Armstrong AJ,Eisenberger MA,Halabi S,et al.Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer [J].Eur Urol,2012,61 (3):549-559. 被引量:1

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部