摘要
为分析我国水貂阿留申病(Aleutian disease,AD)跨宿主传播的分子机制,扩增获得一株吉林地区水貂阿留申病毒(Aleutian disease virus,ADV)VP2基因高变区片段。序列分析表明,第235位存在与参考毒株不同的氨基酸位点,进化树分析结果表明,该毒株与丹麦高致病毒株ADV-K亲缘关系较近。ADV第235位氨基酸位点可能与病毒的感染能力相关。
To analyze the molecular mechanisms of cross-host transmission of the Aleutian mink disease virus（ADV）,the hypervariable region fragment of the VP2 gene of the ADV in Jilin Province（China）was amplified.Sequencing analyses showed diversity at residue 174 by comparison with other VP2 genes in GenBank.The phylogenetic tree indicated that the ADV-JL strain had a close relationship with the highly pathogenic strain from Denmark：ADV-K.Results implied that residue 174 may be associated with ADV infectivity.
出处
《病毒学报》
CAS
CSCD
北大核心
2015年第3期226-230,共5页
Chinese Journal of Virology
基金
吉林省科技发展计划项目任务书201201001
吉林省科技攻关计划:20140204074NY
关键词
水貂阿留申病毒
VP2高变区
跨宿主传播
Aleutian mink disease virus
Hypervariable region of the VP2gene
Cross-host transmission
