期刊文献+

肾母细胞瘤的研究进展 被引量:8

Research advance of Wilms' tumor
下载PDF
导出
摘要 肾母细胞瘤(Wilms'tumor,WT)是儿童肾脏最常见的恶性肿瘤,其发病是多基因协同作用的复杂过程。其主要临床表现为腹胀或腹部包块,手术治疗是WT的主要治疗手段,不推荐正式的淋巴结清扫术。肾母细胞瘤对放化疗敏感,根据分期及组织学分型进行辅助放化疗是综合治疗较为重要的部分。其预后与肿瘤分期、组织学分型、年龄及生物预后标志物有关。 Wilmsˊtumor( WT)is the common kidney tumor in children,and the Pathogenesis is a comPlex synergy Process enrolled many genes. Abdominal distension and mass are the main clinical manifestation. OPeration is the main treatment,and formal lymPhnode dissection is not recommended. Wilmsˊtumor is sensitive to radiochemotheraPy, and adjuvant radiochemotheraPy is an imPortant Part of the comPrehensive theraPy in Wilmsˊtumor. The Prognosis is related with the stage,histological tyPe,age and biological Prognostic marker.
出处 《现代肿瘤医学》 CAS 2015年第13期1928-1931,共4页 Journal of Modern Oncology
关键词 肾母细胞瘤 临床表现 治疗 预后 Wilmsˊtumor clinical manifestation treatment Prognosis
  • 相关文献

参考文献27

  • 1Pastore G,Znaor A,Spreafico F,et al. Malignant renal tumours in-cidence and survival in european children (1978 - 1997) : Reportfrom the automated childhood cancer information system project[J]. Eur J Cancer,2006,42(13) :2103 -2114. 被引量:1
  • 2Davidoff AM. Wilms'tumor[ J] . Adv Pediatr,2012,59 ( 1 ) :247 -267. 被引量:1
  • 3Sonn G, Shortliffe LM. Management of Wilms'tumor: Current stand-ard of care[ J]. Nat Clin Pract Urol,2008,5( 10) :551 -560. 被引量:1
  • 4Roberts SG. Transcriptional regulation by WT1 in development[J]. Curr Open Genet Dev,2005,15 (5) :542 - 547. 被引量:1
  • 5Sredni ST,Gadd S,Huang CC,et al. Subsets of very low risk Wilms-tumor show distinctive gene expression,histologic and clinical fea-tures[J]. Clin Cancer Res,2009,9( 12) :6800 -6809. 被引量:1
  • 6Safford SD, Goyeau D, Freemerman AJ, et al. Fine mapping ofWilmsztumors with 16q loss of heterozygosity localizes the putativetumor suppressor gene to a region of 6. 7 megabasesf J] . Ann Surg0ncol,2003,10(2) :136 -143. 被引量:1
  • 7Schenk JP, Schrader C, Zieger B, et al. Reference radiology innephroblastoma . Accurtcy and relevance for preoperative chemo-therapy[J]. Hofo,2006,178(1) :38 -45. 被引量:1
  • 8Al Shanafey S,Yanchar NL,Schmidt MH,et al. CT - estimated vol-ume of Wilms'tumor can predict weight [ J ]. J Pediatr Hematol On-col,2005 ,27(6) :990-994. 被引量:1
  • 9Meyer JS,Harty MP,Khademian Z. Imaging of neuroblastoma andWilms"tumor[ J]. Magn Reson Imaging Clin N Am,2002,10(2):275 -302. 被引量:1
  • 10Metzger ML,Dome JS. Current therapy for wilms^tumor[ J]. On-cologist,2005,10(10) :815 -826. 被引量:1

二级参考文献59

  • 1Abd El-AM HH, Habib EE, Mishrif MM. Wilms' tumor: the experience of the pediatric unit of Kasr E1-Aini center of radiation oncology and nuclear medicine (NEMROCK) [J]. J Egypt Nat Canc Inst,2005,17(4) :308. 被引量:1
  • 2Fukuzawa M. Treatment strategy for children with Wilms' tumor[J]. Nippon Geka Gakkai Zasshi, 2005,106 ( 7 ) : 422. 被引量:1
  • 3D' Angio GJ, Breslow N, Beckwith JB, et al. Treatment of Wilms' Tumor. Results of the Third National Wilms' Tumor Study[J].Cancer, 1989,64(2) :349. 被引量:1
  • 4Ludwig R, Weirich A, Potter R, et al. Preoperative chemotherapy of nephroblastoma. Preliminary results of the SIOP- 9/ GPO therapy study [J]. Klin Padiatr, 1992,204 (4) : 204. 被引量:1
  • 5Shamberger R C, Guthrie K A, Ritchey M L, et al. Surgery- related factors and local recurrence of Wilms' tumor in National Wilms' Tumor Study 4 [ J ]. Ann Surg, 1999,229 (2) :292. 被引量:1
  • 6Greenberg M, Bumweit C, Filler R, et al. Preoperative chemotherapy for children with Wilms' tumor [J].J Pediatr Surg, 1991,26( 8 ) :949. 被引量:1
  • 7Deraedt K, Debiec Rychter M, Sciot R, et al. Radiation-associated synovial sarcoma of the lung following radiotherapy for pulmonary metastasis of Wilms' tumor[J]. Histopathology ,2006,48(4) :473. 被引量:1
  • 8Graf N ,Toumade MF,De Kraker J. The role of preoperstive chemotherapy in the management of Wilms' Tumor (the SlOP studies ) International Society of Pediatric Oncology[J].Urol Clin North Am,2000,27(3) :443. 被引量:1
  • 9Godzinski J ,Tournade MF, Kraker JD ,et al. The role of preoperative ehemotherapy in the treatment of nephroblastoma : the SIOP experience[J]. Semin Urol Oncol, 1999,17( 1 ) : 28. 被引量:1
  • 10Michael G, Levien MD, Karn A, et al. postopertive chemotherapy in the National Wilms' Tumor studies [J].Semin Urol Oncol, 1999,17 ( 1 ) :40. 被引量:1

共引文献17

同被引文献61

  • 1杨静薇,蒋慧,陆正华,邵静波,李红.儿童肾母细胞瘤个体化综合治疗的疗效分析[J].上海交通大学学报(医学版),2011,31(6):817-820. 被引量:7
  • 2Pierce J,Murphy AJ,Panzer A, et al. SIX2 Effects on Wilms Tumor Biology [ J 1. Transl Oncol, 2014,7 ( 6 ) : 800 - 811. 被引量:1
  • 3Murphy AJ, Axt JR, de Caestecker C, et al. Molecular characteriza- tion of Wilms' tumor from a ed region of sub-Saha- ran Africa [ J ]. Int J Cancer,2012,131 ( 6 ) : E983 - 994. 被引量:1
  • 4Xu J, Liu H, Park JS, et al. Osrl acts downstream of and interactssynergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis [ J ]. Development ( Cambridge, England ) , 2014,141 (7) :1442 - 1452. 被引量:1
  • 5Zhou P, Chen T, Fang Y, et al. Down-regulated Six2 by knockdown of neurofibro min results in apoptosis of metanephric mesenchyme cells in vitro[J]. Mol Cell Biochem,2014,390(1/2) :205 -213. 被引量:1
  • 6Pierce J,Murphy AJ,Panzer A, et al. SIX2 Effects on Wilms Tumor Biology[ J1. Transl Oncol,2014,7(6) :800-811. 被引量:1
  • 7He G, Tavella S, Hanley KP, et al. Inactivation of Six2 in mouse i- dentifies a novel genetic mechanism controlling development and growth of the cranial base[ J]. Dev Boil ,2010,344 ( 2 ) :720 - 730. 被引量:1
  • 8Kiefer SM, Robbins L, Rauchman M. Conditional expression of Wnt9b in Six2-positive ceils disrupts stomach and kidney function [J]. PIoS One,2012,7(8) :e43098. 被引量:1
  • 9李欣,安玉,杨志勇.儿童肾母细胞瘤的CT诊断[J].中华放射学杂志,1998,32(3):185-187. 被引量:34
  • 10曹卉娟,邢建民,刘建平.视觉模拟评分法在症状类结局评价测量中的应用[J].中医杂志,2009,50(7):600-602. 被引量:799

引证文献8

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部