摘要
目的探讨分析土三七致酒精性肝硬化患者肝小静脉闭塞综合征的临床特点。方法回顾性分析本科室收治的4例酒精性肝硬化患者服用土三七所致的肝小静脉闭塞综合征的临床诊治资料。结果本组病例具有以下临床特点:病例均为男性,年龄在45岁以上;多因骨折、腰痛、腰椎间盘突出等骨伤科疾病服用土三七药酒;均有长期饮酒史,发病前已确诊酒精性肝硬化;患者均有较典型的症状和体征,但没有明显的肝脏增大;病例结合详细的病史、CT或磁共振、下腔静脉造影等可明确诊断;病情的严重程度和服用土三七的总剂量有一定关系。结论土三七引起酒精性肝硬化患者肝小静脉闭塞综合征,长期饮酒、酒精性肝硬化可能是土三七导致HVOD发生的一个重要危险因素。
Objective To analysis and explore the clinical features of hepatic veno-occlusive disease（HVOD） induced by gynura segetum in the patients with alcoholic liver cirrhosis. Methods The data was collected and analysed from 4 patients hospitalized in our department from October 2012 to June 2014. The diagnosis of HVOD for all the patients was made by the drug use history, typical clinical manifestation, biochemical and iconographic examination, CT or MRI. Results The results showed that this group of cases has the following clinical features： all patients are male and the age was elder than 45 years old; all patients with history of long-term use of gynura segetum, one of Chinese medical herbs, because of the suffering orthopaedic disease such as fractures, lumbago, lumbar disc. Before the occuring of HVOD paroxysm, all of the patients had basis of alcoholic liver cirrhosis, with the average of 10 years of alcohol-drinking. All the cases manifested the typical clinical symptoms and sign of HVOD, but without hepatomegaly. The diagnosis of HVOD in all of patients was finally confirmed by both of CT or MRI and Inferior vena cava angiography. There was a positive relationship between the severity of the disease and the total dose of gynura segetum. Conclusions Longterm alcohol drinking may be an important risk factor for the severity of HVOD induce by gynura segetum. It is the first report of hepatic veno-occlusive disease induced by gynura segetum on the basis of alcoholic liver cirrhosis.
出处
《中国肝脏病杂志（电子版）》
CAS
2015年第1期51-54,共4页
Chinese Journal of Liver Diseases：Electronic Version
基金
江苏省临床医学科技专项(BL2013004)
关键词
肝小静脉闭塞综合征
土三七
酒精性肝硬化
Hepatic veno-occlusive disease
HVOD
Gynura segetum
Alcoholic liver disease
