摘要
对于急性中风患者施行早期有效的溶栓治疗,恢复缺血脑组织的血流和功能已成为临床公认有效的治疗手段。但溶栓治疗有严格的时间窗限制,且并发症很多,为了解决这一难题,"缺血预适应"对脑组织缺血/再灌注损伤保护作用的研究进入了人们的视线。目前已有研究证明远隔缺血后适应的脑保护作用。但作用机制尚不明确。因此本课题的目的是应用远隔缺血后适应模型即脑缺血后给予远隔器官(双下肢缺血处理)研究远隔缺血后适应对脑缺血的保护作用及机制。基于既往的研究结果,我们提出了这样假说:脑缺血再灌注时给予双侧或单侧下肢的缺血可以对脑缺血造成的损伤具有保护作用,其保护机制可能是多方面,一方面,可能通过减轻缺血再灌注的损伤,从而减轻了缺血引起的血脑屏障的损伤;另一方面,可能远隔器官的缺血产生了神经保护物质。本课题研究,为将来急性脑梗塞的临床治疗,特别是通过神经保护治疗措施,延长治疗时间窗提供新的理论依据。
For patients with acute stroke early and effective implementation of thrombolytic therapy to restore blood flow and function of ischemic brain tissue has become recognized as an effective clinical treatment. Thrombolytic therapy but there are strict time window constraints, and a lot of complications, in order to solve this problem, ＂ischemic preconditioning＂ The study of cerebral ischemia / reperfusion injury into the people＇s attention. At present, studies have shown that the protective effect of adaptation after ischemic brain distant. But the mechanism is not clear. So the purpose of this project is to adapt the model after applying distant ischemic cerebral ischemia given that distant organs（double limb ischemia treatment） study distant after ischemia protective effect and mechanism of adaptation cerebral ischemia.Based on previous findings, we propose such a hypothesis： given bilateral or unilateral lower limb ischemia can cause damage to the brain has a protective effect of ischemic cerebral ischemia and reperfusion, the protective mechanism may be multifaceted, on the one hand probably by reducing ischemia-reperfusion injury, thus reducing the blood-brain barrier damage caused by ischemia; on the other hand, may be distant organ ischemia produced a neuroprotective substances. This research for future clinical treatment of acute cerebral infarction, particularly through neuroprotective treatment, prolonged treatment time window to provide a new theoretical basis.
出处
《心血管病防治知识（学术版）》
2015年第6期154-157,共4页
Prevention and Treatment of Cardiovascular Disease
