摘要
目的:研究Sema4D、CXCR4在肺癌组织中的表达,探讨其与肺癌患者的预后及临床病理因素的关系。方法:运用免疫组化方法检测95例肺癌组织标本及20例正常肺组织标本中的Sema4D、CXCR4表达水平,并进行对比。结果:肺癌组织标本中Sema4D、CXCR4的阳性表达率分别为71.6%、61.1%,而正常组织中的表达为10.0%、0,差异有统计学意义(P<0.05);Sema4D、CXCR4表达与组织学分级、临床分期及淋巴结转移有关,与肿瘤大小无关。结论:肺癌患者组织中Sema4D、CXCR4的表达与肺癌的临床病理进展有关,可能是判定疾病的病理进展和预后的重要的生物标志物。
Objective：To study the clinicopathologic factors of the patients with lung cancer and correlation between the expression of Sema4 D,CXCR4 in the tissues of lung cancer and prognosis.Method：The expression of Sema4 D,CXCR4 were tested by immunohistochemistry in the tissues of 95 cases of lung cancer and 20 cases of normal controls.Result：The positive rates of Sema4 D and CXCR4 expression were 71.6% and 61.1% in the tissues of 95 cases of lung cancer.However,the positive rates of Sema4 D expression was only 10.0% and the expression of CXCR4 was negative in normal lung tissues.There were significant differences between lung cancer and normal controls（P〈0.05）.The expression of Sema4 D and CXCR4 were significantly correlated with histological grades,clinical stages and lymph node metastasis,but excluding tumor sizes.Conclusion：Sema4D and CXCR4 expression in the tissues of patients with lung cancer are associated with the clinical and pathological progress of lung cancer.They may be the important biomarkers of pathological progression and prognosis.
出处
《中外医学研究》
2015年第18期1-3,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
