摘要
目的通过主动监测的方式获取我院内分泌病区因药物不良反应(ADR)入院的发生率及主要特征,为临床安全用药提供参考。方法临床药师通过床旁问诊方式采集内分泌病区2011年1月至2013年12月因药物不良反应入院患者的详细资料,并对药物不良反应类型、临床表现、怀疑药物、过敏史、住院时间、住院费用以及转归情况进行分析。结果 6 914例入院患者中共有40例因药物不良反应入院,占0.58%,男性13例,女性27例,平均年龄(54.82±15.85)岁,平均住院费用(10622.86±6 719.48)元,住院天数(12.85±7.57)d,其中A型药物不良反应有34例(85.0%),B型药物不良反应有6例(15.0%)。40例药物不良反应共11种药物不良反应表现类型,涉及怀疑药物27种,主要的药物不良反应表现有低血糖、肾小管损害继发低磷软骨,类固醇糖尿病,粒细胞缺乏(减少)、胰岛素过敏、低血钾,肝酶升高,胰岛素自身免疫综合症,电解质紊乱,甲亢以及甲减,涉及的怀疑药物主要有胰岛素、口服降糖药物,降糖中成药(保健品)、甲巯咪唑、阿德福韦酯、肾上腺皮质激素等。结论内分泌病区因药物不良反应住院的比例0.58%,但引起药物不良反应的多为内分泌的常用药物,药物不良反应表现如低血糖、低血钾、电解质紊乱等与内分泌系统疾病临床表现相似,常常会影响诊断,延误治疗,因此在诊疗过程中,应重视药物的药物不良反应因素。
OBJECTIVE To obtain the prevalence of hospital admissions due to adverse drug reactions（ ADRs） and study the main features of the ADRs. METHODS The clinical data of the inpatients of endocrinology ward from January 2011 to December 2013 were collected by clinical pharmacists by interviewing with patients. And the types of ADRs,clinical features,suspicious drugs,hospital stays,cost and turnover were analyzed. RESULTS Among the 6 914 patients,40 patients（ 0. 58%） were hospitalized due to ADRs,including 13 males and 27 females. The mean age was（ 54. 82 ± 15. 85） y. The mean hospital stay was（ 12. 85 ± 7. 57） d.The mean cost was（ 10 622. 86 ± 6 719. 48） Yuan. The 40 hospital admissions were attributed to 11 types of ADRs caused by 27 suspected drugs. The ADRs included hypoglycaemia,agranulocytosis（ neutropenia）,hypokalemic,hypophosphatemic osteomalacia secondary to renal tubular damage,electrolyte disturbances,elevated hepatenzyme,insulin allergy,insulin autoimmune syndrome,hypothyroidism,and hyperthyroidism. The suspicious drugs included antidiabetics（ insulin,oral antidiabetics and traditional Chinese medicines）,methimazole,adefovir and corticoids. CONCLUSION The prevalence of hospital admission due to ADRs in the endocrinology ward was 0. 47%. The clinical characteristics of the ADRs such as hypoglycaemia,hypokalemic and electrolyte disturbances were similar to the clinical manifestation of some endocrine system diseases,which might affect the diagnosis and delay the therapy. So,we should pay attention to ADRs during the process of diagnosis and therapy.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2015年第12期1066-1069,共4页
Chinese Pharmaceutical Journal
基金
解放军总医院科技创新苗圃基金资助项目(13KMM46)
关键词
因不良反应住院
内分泌
临床药师
不良反应
hospitalization
endocrinology
clinical pharmacist
adverse drug reaction
